Please use this identifier to cite or link to this item: https://doi.org/10.1021/cc049900s
Title: Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG
Authors: Uttamchandani, M. 
Walsh, D.P.
Khersonsky, S.M.
Huang, X.
Yao, S.Q. 
Chang, Y.-T.
Issue Date: Nov-2004
Source: Uttamchandani, M., Walsh, D.P., Khersonsky, S.M., Huang, X., Yao, S.Q., Chang, Y.-T. (2004-11). Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG. Journal of Combinatorial Chemistry 6 (6) : 862-868. ScholarBank@NUS Repository. https://doi.org/10.1021/cc049900s
Abstract: A novel and highly diverse tagged triazine library incorporating a triethylene glycol-based linker was synthesized using an orthogonal combinatorial approach on the solid phase and covalently immobilized on a glass substrate as a small molecule microarray (SMM). The SMM was screened with a fluorophore-conjugated human IgG, and 4 novel binders from a library of 2688 compounds were identified from the fully spatially addressable array without the need for compound decoding. Using surface plasmon resonance (SPR) analysis, binding seen on the array was confirmed, and a binding constant as low as K d = 2.02 × 10-6 M was measured.
Source Title: Journal of Combinatorial Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/94227
ISSN: 15204766
DOI: 10.1021/cc049900s
Appears in Collections:Staff Publications

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