Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/94121
Title: Kinetic studies of mercuric chloride on Na+ K+-ATPase in the kidney of fancy carp, Cyprinus carpio
Authors: Lan, W.G.
Wong, M.K. 
Sin, Y.M. 
Issue Date: Jul-1993
Citation: Lan, W.G.,Wong, M.K.,Sin, Y.M. (1993-07). Kinetic studies of mercuric chloride on Na+ K+-ATPase in the kidney of fancy carp, Cyprinus carpio. Comparative Biochemistry and Physiology -- Part B: Biochemistry and 105 (3-4) : 713-717. ScholarBank@NUS Repository.
Abstract: 1. 1. The effect of mercuric chloride on the substrate and ionic activation kinetics of Na+ K+-ATPase activity in the kidney of fancy carp (Cyprinus carpio) was determined. 2. 2. Mercuric inhibition was shown to be a classical competitive nature with respect to substrate ATP activated Na+ K+-ATPase, in that the apparent Km values were increased without a significant change in the apparent Vmax values. 3. 3. Mercuric inhibition was a mixed noncompetitive nature with respect to Na+-activated Na+ K+-ATPase, where the apparent Km values were increased but the apparent Vmax values were decreased. 4. 4. Mercuric inhibition was a pure noncompetitive nature with respect to Mg2+ and K+-activated Na+ K+-ATPase, in that the apparent Vmax values were decreased but not the apparent Km values. 5. 5. Based on the above results, we proposed a possible kinetic model for elucidating the biochemical mechanism of inhibition of mercuric chloride on Na+ K+-ATPase in the kidney of fancy carp. © 1993.
Source Title: Comparative Biochemistry and Physiology -- Part B: Biochemistry and
URI: http://scholarbank.nus.edu.sg/handle/10635/94121
ISSN: 03050491
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Page view(s)

28
checked on Nov 16, 2018

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.