Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jorganchem.2008.07.039
Title: Induction of apoptosis by hexaosmium carbonyl clusters
Authors: Kong, K.V.
Leong, W.K. 
Lim, L.H.K.
Keywords: Apoptosis
Cancer
Cluster compounds
Osmium
Issue Date: 15-Mar-2009
Source: Kong, K.V., Leong, W.K., Lim, L.H.K. (2009-03-15). Induction of apoptosis by hexaosmium carbonyl clusters. Journal of Organometallic Chemistry 694 (6) : 834-839. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jorganchem.2008.07.039
Abstract: A number of tri- and hexaosmium carbonyl cluster derivatives were screened for cytotoxicity against five cancer cell lines, and the hexaosmium carbonyl clusters Os6(CO)18 and Os6(CO)16(NCCH3)2 were found to be active against four of these, viz., ER+ breast carcinoma (MCF-7), ER-breast carcinoma (MDA-MB-231), metastatic colorectal adenocarcinoma (SW620) and hepatocarcinoma (Hepg2), with IC50 values as low as 6 μM. Studies on their mode of action with the MDA-MB-231 cell line pointed to the induction of apoptosis, as has been found earlier for the trinuclear cluster Os3(CO)10(NCCH3)2. © 2008 Elsevier B.V. All rights reserved.
Source Title: Journal of Organometallic Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/94043
ISSN: 0022328X
DOI: 10.1016/j.jorganchem.2008.07.039
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