Please use this identifier to cite or link to this item:
|Title:||Highly enantioselective preparation of fluorinated phosphonates by michael addition of α-fluoro-β-ketophosphonates to nitroalkenes|
|Citation:||Kwiatkowski, J., Lu, Y. (2014). Highly enantioselective preparation of fluorinated phosphonates by michael addition of α-fluoro-β-ketophosphonates to nitroalkenes. Asian Journal of Organic Chemistry 3 (4) : 458-461. ScholarBank@NUS Repository. https://doi.org/10.1002/ajoc.201300211|
|Abstract:||Fluorinated phosphonates are excellent surrogates of phosphates, outperforming the latter in terms of hydrolytic stability in biological systems while retaining similar activities. However, methods for preparing chiral fluorinated phosphonates are very limited. In this report, racemic α-fluoro-β-ketophosphonates were used in stereoselective Michael addition to nitroalkenes promoted by trifunctional thiourea organocatalyst. Highly functionalised α-fluoro-β-keto-γ-nitrophosphonates were obtained in high yields of 84-99% with excellent stereochemical control (96-99% ee and 3:1-34:1 d.r.). © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Asian Journal of Organic Chemistry|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 19, 2018
WEB OF SCIENCETM
checked on Jun 11, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.