Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chroma.2004.07.018
Title: Enantioseparation on mono(6 A-N-allylamino-6 A-deoxy) permethylated β-cyclodextrin covalently bonded silica gel
Authors: Lai, X.-H.
Ng, S.-C. 
Keywords: Chiral stationary phases
Flavanone
Liquid chromatography
Permethylated cyclodextrin
Issue Date: 3-Dec-2004
Citation: Lai, X.-H., Ng, S.-C. (2004-12-03). Enantioseparation on mono(6 A-N-allylamino-6 A-deoxy) permethylated β-cyclodextrin covalently bonded silica gel. Journal of Chromatography A 1059 (1-2) : 53-59. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chroma.2004.07.018
Abstract: A chiral selector, mono(6 A-N-allylamino-6 A-deoxy) permethylated β-cyclodextrin, was synthesized through a facile synthetic route and chemically immobilized onto porous silica gel via hydrosilylation to afford a cyclodextrin based chiral stationary phase MeCD-CSP. This chiral stationary phase exhibited good enantioselectivity under standard HPLC conditions. The optimal resolution of 1-(p-bromophenyl)ethanol and bromopheniramine was achieved under normal-phase conditions using a mobile phase comprising n-hexane (hexane) and 2-propanol (IPA). The enantioseparation of warfarin, suprofen and a series of flavanones under reversed-phase conditions were optimized and efficient enantioseparations for these analytes were obtained. © 2004 Elsevier B.V. All rights reserved.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/93747
ISSN: 00219673
DOI: 10.1016/j.chroma.2004.07.018
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