Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.aca.2005.08.064
Title: Enantioselective separation in capillary electrophoresis using a novel mono-6A-propylammonium-β-cyclodextrin as chiral selector
Authors: Tang, W.
Muderawan, I.W.
Ng, S.-C.
Chan, H.S.O. 
Keywords: 6A-Propylammonium-6A-deoxy-β- cyclodextrin chloride
Capillary electrophoresis
Cationic β-cyclodextrin
Enantionmeric separation
Issue Date: 5-Jan-2006
Citation: Tang, W., Muderawan, I.W., Ng, S.-C., Chan, H.S.O. (2006-01-05). Enantioselective separation in capillary electrophoresis using a novel mono-6A-propylammonium-β-cyclodextrin as chiral selector. Analytica Chimica Acta 555 (1) : 63-67. ScholarBank@NUS Repository. https://doi.org/10.1016/j.aca.2005.08.064
Abstract: The chiral resolving ability of a novel single-isomer cationic β-cyclodextrin (CD), mono-6A-propylammonium-6 A-deoxy-β-cyclodextrin chloride (PrAMCD), as a chiral selector in capillary electrophoresis (CE) is reported in this work for the enantioseparation of hydroxy, carboxylic acids and amphoteric analytes. The effect of chiral selector concentration on the resolution was studied. Good resolutions were achieved for hydroxy acids. Optimum resolutions were obtained even at 3.5 mM CD concentration for carboxylic acids. The electrophoretic method showed good linearity and reproducibility in terms of migration times and peak areas, which should make it suitable for routine analysis. In addition, baseline chiral separation of a six-acid mixture was achieved within 20 min. PrAMCD proved to be an effective chiral selector for acidic analytes. © 2005 Elsevier B.V. All rights reserved.
Source Title: Analytica Chimica Acta
URI: http://scholarbank.nus.edu.sg/handle/10635/93743
ISSN: 00032670
DOI: 10.1016/j.aca.2005.08.064
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