Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.tetlet.2011.09.030
Title: Enantioselective organocatalytic synthesis of medicinally privileged 2-amino-4H-chromene-3-carbonitriles via a cascade process
Authors: Du, Z.
Siau, W.-Y.
Wang, J. 
Keywords: Cascade reaction
Chromene
Malononitrile
Organocatalysis
Privileged scaffold
Issue Date: 16-Nov-2011
Source: Du, Z., Siau, W.-Y., Wang, J. (2011-11-16). Enantioselective organocatalytic synthesis of medicinally privileged 2-amino-4H-chromene-3-carbonitriles via a cascade process. Tetrahedron Letters 52 (46) : 6137-6141. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2011.09.030
Abstract: An efficient organocatalytic cascade approach toward medicinally privileged 2-amino-4H-chromene-3-carbonitriles is reported. The enantioselective synthesis of these compounds is achieved in high yields and good to high ee values (up to 96% yield and 89% ee) using bifunctional amine-thiourea organocatalysts developed in our laboratory. © 2011 Elsevier Ltd. All rights reserved.
Source Title: Tetrahedron Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/93740
ISSN: 00404039
DOI: 10.1016/j.tetlet.2011.09.030
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