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https://doi.org/10.1016/j.tetlet.2011.09.030
Title: | Enantioselective organocatalytic synthesis of medicinally privileged 2-amino-4H-chromene-3-carbonitriles via a cascade process | Authors: | Du, Z. Siau, W.-Y. Wang, J. |
Keywords: | Cascade reaction Chromene Malononitrile Organocatalysis Privileged scaffold |
Issue Date: | 16-Nov-2011 | Citation: | Du, Z., Siau, W.-Y., Wang, J. (2011-11-16). Enantioselective organocatalytic synthesis of medicinally privileged 2-amino-4H-chromene-3-carbonitriles via a cascade process. Tetrahedron Letters 52 (46) : 6137-6141. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2011.09.030 | Abstract: | An efficient organocatalytic cascade approach toward medicinally privileged 2-amino-4H-chromene-3-carbonitriles is reported. The enantioselective synthesis of these compounds is achieved in high yields and good to high ee values (up to 96% yield and 89% ee) using bifunctional amine-thiourea organocatalysts developed in our laboratory. © 2011 Elsevier Ltd. All rights reserved. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/93740 | ISSN: | 00404039 | DOI: | 10.1016/j.tetlet.2011.09.030 |
Appears in Collections: | Staff Publications |
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