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|Title:||Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins|
|Source:||Zhong, F., Yao, W., Dou, X., Lu, Y. (2012-08-03). Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins. Organic Letters 14 (15) : 4018-4021. ScholarBank@NUS Repository. https://doi.org/10.1021/ol301855w|
|Abstract:||The first highly enantioselective decarboxylative addition of β-ketoacids to isatins mediated by a bifunctional tertiary amine-thiourea catalyst has been developed, allowing facile synthesis of biologically important 3-hydroxy oxindoles in good yields and excellent enantioselectivities. The method reported represents a valuable approach of utilizing β-ketoacids as synthetic equivalents of aryl/alkyl methyl ketone enolates. © 2012 American Chemical Society.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
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