Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol301855w
Title: Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins
Authors: Zhong, F.
Yao, W.
Dou, X.
Lu, Y. 
Issue Date: 3-Aug-2012
Source: Zhong, F., Yao, W., Dou, X., Lu, Y. (2012-08-03). Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins. Organic Letters 14 (15) : 4018-4021. ScholarBank@NUS Repository. https://doi.org/10.1021/ol301855w
Abstract: The first highly enantioselective decarboxylative addition of β-ketoacids to isatins mediated by a bifunctional tertiary amine-thiourea catalyst has been developed, allowing facile synthesis of biologically important 3-hydroxy oxindoles in good yields and excellent enantioselectivities. The method reported represents a valuable approach of utilizing β-ketoacids as synthetic equivalents of aryl/alkyl methyl ketone enolates. © 2012 American Chemical Society.
Source Title: Organic Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/93736
ISSN: 15237060
DOI: 10.1021/ol301855w
Appears in Collections:Staff Publications

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