Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.aca.2005.08.034
Title: Enantiomeric separation of 8 hydroxy, 10 carboxylic and 6 dansyl amino acids by mono(6-amino-6-deoxy)-β-cyclodextrin in capillary electrophoresis
Authors: Tang, W.
Muderawan, I.W.
Ng, S.-C.
Chan, H.S.O. 
Keywords: Binding constants
Capillary electrophoresis
Cationic β-cyclodextrin
Enantioseparation
Mono(6-amino-6-deoxy)-β-cyclodextrin
Issue Date: 4-Dec-2005
Source: Tang, W., Muderawan, I.W., Ng, S.-C., Chan, H.S.O. (2005-12-04). Enantiomeric separation of 8 hydroxy, 10 carboxylic and 6 dansyl amino acids by mono(6-amino-6-deoxy)-β-cyclodextrin in capillary electrophoresis. Analytica Chimica Acta 554 (1-2) : 156-162. ScholarBank@NUS Repository. https://doi.org/10.1016/j.aca.2005.08.034
Abstract: The enantioseparation of a wide spectrum of anionic analytes was successfully performed by using mono(6-amino-6-deoxy)-β-cyclodextrin (β-CD-NH2). The effects of buffer pH and selector concentration on migration time and resolution of analytes were studied in detail. Good results were obtained for the chiral separations of hydroxy and carboxylic acids. A clear maximum in selectivity was found for most analytes. The introduced positive charge can greatly improve the chiral recognition ability of β-CD-NH2 towards anionic analytes. The binding constants of eight analytes with β-CD-NH2 were determined and suited well with the mobility difference model (by Wren). Moreover, a standard mixture of five acids was baseline separated within 23 min. © 2005 Elsevier B.V. All rights reserved.
Source Title: Analytica Chimica Acta
URI: http://scholarbank.nus.edu.sg/handle/10635/93733
ISSN: 00032670
DOI: 10.1016/j.aca.2005.08.034
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