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Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bmcl.2007.06.035
DC FieldValue
dc.titleDumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I
dc.contributor.authorLi, X.
dc.contributor.authorTao Ng, M.T.
dc.contributor.authorWang, Y.
dc.contributor.authorLiu, X.
dc.contributor.authorLi, T.
dc.date.accessioned2014-10-16T08:26:35Z
dc.date.available2014-10-16T08:26:35Z
dc.date.issued2007-09-01
dc.identifier.citationLi, X., Tao Ng, M.T., Wang, Y., Liu, X., Li, T. (2007-09-01). Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic and Medicinal Chemistry Letters 17 (17) : 4967-4971. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2007.06.035
dc.identifier.issn0960894X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/93634
dc.description.abstractA dumbbell-shaped circular oligonucleotide containing topoisomerase I-binding sites and two mismatched base pairs in its sequence has been designed and synthesized. Our further studies demonstrate that this particularly designed oligonucleotide displays an IC50 value of 9 nM in its inhibition on the activity of human topoisomerase I, a magnitude smaller than that of camptothecin, an anticancer drug currently in clinical use. © 2007 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bmcl.2007.06.035
dc.sourceScopus
dc.subjectCircular oligonucleotides
dc.subjectEnzyme inhibitor
dc.subjectHuman topoisomerase I
dc.subjectStable hairpins
dc.typeArticle
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1016/j.bmcl.2007.06.035
dc.description.sourcetitleBioorganic and Medicinal Chemistry Letters
dc.description.volume17
dc.description.issue17
dc.description.page4967-4971
dc.description.codenBMCLE
dc.identifier.isiut000249151700048
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