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|Title:||Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I|
Tao Ng, M.T.
Human topoisomerase I
|Citation:||Li, X., Tao Ng, M.T., Wang, Y., Liu, X., Li, T. (2007-09-01). Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic and Medicinal Chemistry Letters 17 (17) : 4967-4971. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2007.06.035|
|Abstract:||A dumbbell-shaped circular oligonucleotide containing topoisomerase I-binding sites and two mismatched base pairs in its sequence has been designed and synthesized. Our further studies demonstrate that this particularly designed oligonucleotide displays an IC50 value of 9 nM in its inhibition on the activity of human topoisomerase I, a magnitude smaller than that of camptothecin, an anticancer drug currently in clinical use. © 2007 Elsevier Ltd. All rights reserved.|
|Source Title:||Bioorganic and Medicinal Chemistry Letters|
|Appears in Collections:||Staff Publications|
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