Please use this identifier to cite or link to this item:
|Title:||Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I|
Tao Ng, M.T.
Human topoisomerase I
|Source:||Li, X., Tao Ng, M.T., Wang, Y., Liu, X., Li, T. (2007-09-01). Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic and Medicinal Chemistry Letters 17 (17) : 4967-4971. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2007.06.035|
|Abstract:||A dumbbell-shaped circular oligonucleotide containing topoisomerase I-binding sites and two mismatched base pairs in its sequence has been designed and synthesized. Our further studies demonstrate that this particularly designed oligonucleotide displays an IC50 value of 9 nM in its inhibition on the activity of human topoisomerase I, a magnitude smaller than that of camptothecin, an anticancer drug currently in clinical use. © 2007 Elsevier Ltd. All rights reserved.|
|Source Title:||Bioorganic and Medicinal Chemistry Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 13, 2018
WEB OF SCIENCETM
checked on Jan 10, 2018
checked on Feb 18, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.