Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bmcl.2007.06.035
Title: Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I
Authors: Li, X.
Tao Ng, M.T.
Wang, Y.
Liu, X.
Li, T. 
Keywords: Circular oligonucleotides
Enzyme inhibitor
Human topoisomerase I
Stable hairpins
Issue Date: 1-Sep-2007
Citation: Li, X., Tao Ng, M.T., Wang, Y., Liu, X., Li, T. (2007-09-01). Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I. Bioorganic and Medicinal Chemistry Letters 17 (17) : 4967-4971. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bmcl.2007.06.035
Abstract: A dumbbell-shaped circular oligonucleotide containing topoisomerase I-binding sites and two mismatched base pairs in its sequence has been designed and synthesized. Our further studies demonstrate that this particularly designed oligonucleotide displays an IC50 value of 9 nM in its inhibition on the activity of human topoisomerase I, a magnitude smaller than that of camptothecin, an anticancer drug currently in clinical use. © 2007 Elsevier Ltd. All rights reserved.
Source Title: Bioorganic and Medicinal Chemistry Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/93634
ISSN: 0960894X
DOI: 10.1016/j.bmcl.2007.06.035
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

6
checked on Aug 16, 2018

WEB OF SCIENCETM
Citations

6
checked on Jul 31, 2018

Page view(s)

20
checked on May 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.