Please use this identifier to cite or link to this item:
|Title:||Discovery of a structural-element specific g-quadruplex "light-up" probe|
|Citation:||Zhang, L., Er, J.C., Ghosh, K.K., Chung, W.J., Yoo, J., Xu, W., Zhao, W., Phan, A.T., Chang, Y.-T. (2014-01-20). Discovery of a structural-element specific g-quadruplex "light-up" probe. Scientific Reports 4 : -. ScholarBank@NUS Repository. https://doi.org/10.1038/srep03776|
|Abstract:||The development of a fluorescent probe capable of detecting and distinguishing the wide diversity of G-quadruplex structures is particularly challenging. Herein, we report a novel BODIPY-based fluorescent sensor (GQR) that shows unprecedented selectivity to parallel-stranded G-quadruplexes with exposed ends and four medium grooves. Mechanistic studies suggest that GQR associates with G-quadruplex grooves close to the end of the tetrad core, which may explain the dye's specificity to only a subset of parallel structures. This specific recognition favours the disaggregation of GQR in aqueous solutions thereby recovering the inherent fluorescence of the dye. Due to its unique features, GQR represents a valuable tool for basic biological research and the rapid discovery of novel, specific ligands that target similar structural features of G-quadruplexes.|
|Source Title:||Scientific Reports|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 20, 2018
WEB OF SCIENCETM
checked on Sep 5, 2018
checked on Aug 3, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.