Please use this identifier to cite or link to this item: https://doi.org/10.1038/srep03776
Title: Discovery of a structural-element specific g-quadruplex "light-up" probe
Authors: Zhang, L.
Er, J.C.
Ghosh, K.K.
Chung, W.J.
Yoo, J.
Xu, W.
Zhao, W.
Phan, A.T.
Chang, Y.-T. 
Issue Date: 20-Jan-2014
Source: Zhang, L., Er, J.C., Ghosh, K.K., Chung, W.J., Yoo, J., Xu, W., Zhao, W., Phan, A.T., Chang, Y.-T. (2014-01-20). Discovery of a structural-element specific g-quadruplex "light-up" probe. Scientific Reports 4 : -. ScholarBank@NUS Repository. https://doi.org/10.1038/srep03776
Abstract: The development of a fluorescent probe capable of detecting and distinguishing the wide diversity of G-quadruplex structures is particularly challenging. Herein, we report a novel BODIPY-based fluorescent sensor (GQR) that shows unprecedented selectivity to parallel-stranded G-quadruplexes with exposed ends and four medium grooves. Mechanistic studies suggest that GQR associates with G-quadruplex grooves close to the end of the tetrad core, which may explain the dye's specificity to only a subset of parallel structures. This specific recognition favours the disaggregation of GQR in aqueous solutions thereby recovering the inherent fluorescence of the dye. Due to its unique features, GQR represents a valuable tool for basic biological research and the rapid discovery of novel, specific ligands that target similar structural features of G-quadruplexes.
Source Title: Scientific Reports
URI: http://scholarbank.nus.edu.sg/handle/10635/93612
ISSN: 20452322
DOI: 10.1038/srep03776
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

18
checked on Apr 2, 2018

WEB OF SCIENCETM
Citations

17
checked on Apr 2, 2018

Page view(s)

31
checked on Apr 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.