Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.electacta.2007.07.055
Title: Development of a membrane-based electrochemical immunosensor
Authors: Koh, G.
Agarwal, S. 
Cheow, P.-S.
Toh, C.-S. 
Keywords: Alumina
Glucose oxidase
Immunoglobulin
Immunosensor
Nanostructure
Issue Date: 1-Dec-2007
Citation: Koh, G., Agarwal, S., Cheow, P.-S., Toh, C.-S. (2007-12-01). Development of a membrane-based electrochemical immunosensor. Electrochimica Acta 53 (2) : 803-810. ScholarBank@NUS Repository. https://doi.org/10.1016/j.electacta.2007.07.055
Abstract: A membrane-based electrochemical immunosensor sensitive towards proteins is described, based on nanoporous alumina-modified platinum wire electrodes. The sensing mechanism depends on the blocking of pore channels when the protein antigen molecules bind to antibody molecules attached to the channel walls, impeding the diffusion of redox probe, ferrocenemethanol, towards the sensing platinum wire overlaid by the nanoporous alumina film. The antibody and antigen used in this work were anti-glucose oxidase and glucose oxidase, respectively. The immunosensor showed a low limit of detection of 100 ng L-1 antigen concentration and was selective towards glucose oxidase protein in the presence of another protein, glucothione S-transferase. © 2007 Elsevier Ltd. All rights reserved.
Source Title: Electrochimica Acta
URI: http://scholarbank.nus.edu.sg/handle/10635/93576
ISSN: 00134686
DOI: 10.1016/j.electacta.2007.07.055
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