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Title: Development of a biomimetic nanoporous membrane for the selective transport of charged proteins
Authors: Nguyen, B.T.T.
Ting, E.Z.C.
Toh, C.-S. 
Issue Date: 1-Sep-2008
Source: Nguyen, B.T.T.,Ting, E.Z.C.,Toh, C.-S. (2008-09-01). Development of a biomimetic nanoporous membrane for the selective transport of charged proteins. Bioinspiration and Biomimetics 3 (3) : -. ScholarBank@NUS Repository.
Abstract: We report the use of a micrometer-thick platinum-coated nanoporous membrane for the separation of differently charged proteins. A high field strength of about 25 kV m-1 was applied, using very low transmembrane potentials of ±1.5 V between the platinum-coated membranes. The system mimics the cell membrane function of facilitated transport for specific solutes. The selectivity for Lys:BSA:Mb in a mixed protein solution could be tuned readily between the flux ratios of 2:2:1 and 96:1:12 respectively, by simple variation of the transmembrane potentials from +1.5 V to -1.5 V. The experimental fluxes agreed closely with calculated fluxes derived from a simple electrophoresis- potential shielding model at favourable transmembrane potentials. © 2008 IOP Publishing Ltd.
Source Title: Bioinspiration and Biomimetics
ISSN: 17483182
DOI: 3/035008
Appears in Collections:Staff Publications

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