Please use this identifier to cite or link to this item:
|Title:||Combinatorial Synthesis of a Small-Molecule Library Based on the Vinyl Sulfone Scaffold|
|Citation:||Wang, G., Yao, S.Q. (2003-11-13). Combinatorial Synthesis of a Small-Molecule Library Based on the Vinyl Sulfone Scaffold. Organic Letters 5 (23) : 4437-4440. ScholarBank@NUS Repository. https://doi.org/10.1021/ol035774+|
|Abstract:||(Equation presented) A 30-member library of small molecules based on the vinyl sulfone scaffold was prepared on rink amide resin, using solid phase-based reactions such as oxidation and Horner-Wadsworth-Emmons reaction. The library was designed such that three points of diversity were readily introduced in the library to accommodate the S1′, S 1, and S2 binding pockets of different cysteine proteases, making the strategy suitable for high-throughput generation of potential cysteine protease inhibitors.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 13, 2018
WEB OF SCIENCETM
checked on Jun 11, 2018
checked on Jul 20, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.