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|Title:||Combinatorial Synthesis of a Small-Molecule Library Based on the Vinyl Sulfone Scaffold|
|Citation:||Wang, G., Yao, S.Q. (2003-11-13). Combinatorial Synthesis of a Small-Molecule Library Based on the Vinyl Sulfone Scaffold. Organic Letters 5 (23) : 4437-4440. ScholarBank@NUS Repository. https://doi.org/10.1021/ol035774+|
|Abstract:||(Equation presented) A 30-member library of small molecules based on the vinyl sulfone scaffold was prepared on rink amide resin, using solid phase-based reactions such as oxidation and Horner-Wadsworth-Emmons reaction. The library was designed such that three points of diversity were readily introduced in the library to accommodate the S1′, S 1, and S2 binding pockets of different cysteine proteases, making the strategy suitable for high-throughput generation of potential cysteine protease inhibitors.|
|Source Title:||Organic Letters|
|Appears in Collections:||Staff Publications|
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