Please use this identifier to cite or link to this item: https://doi.org/10.1002/jbm.1029
Title: Chitosan-alginate films prepared with chitosans of different molecular weights
Authors: Yan, X.-L.
Khor, E. 
Lim, L.-Y. 
Keywords: Chitosan-alginate PEC film
Cytotoxicity
Molecular weight
Surface morphology
Water vapor transmission
X-ray diffraction
Issue Date: 2001
Citation: Yan, X.-L., Khor, E., Lim, L.-Y. (2001). Chitosan-alginate films prepared with chitosans of different molecular weights. Journal of Biomedical Materials Research 58 (4) : 358-365. ScholarBank@NUS Repository. https://doi.org/10.1002/jbm.1029
Abstract: Chitosan-alginate polyelectrolyte complex (CS-AL PEC) is water insoluble and more effective in limiting the release of encapsulated materials compared to chitosan or alginate. Coherent CS-AL PEC films have been prepared in our laboratory by casting and drying suspensions of chitosan-alginate coacervates. The objective of this study was to evaluate the properties of the CS-AL PEC films prepared with chitosans of different molecular weights. Films prepared with low-molecular-weight chitosan (Mν × 105) were twice as thin and transparent, as well as 55% less permeable to water vapor, compared to films prepared with high-molecular-weight chitosan (Mν105 and 5.33 × 105 yielded films with similar physical properties. The PEC films exhibited different surface properties from the parent films, and contained a higher degree of chain alignment with the possible formation of new crystal types. The PEC films exhibited good in vitro biocompatibility with mouse and human fibroblasts, suggesting that they can be further explored for biomedical applications. © 2001 John Wiley & Sons, Inc.
Source Title: Journal of Biomedical Materials Research
URI: http://scholarbank.nus.edu.sg/handle/10635/93303
ISSN: 00219304
DOI: 10.1002/jbm.1029
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