Please use this identifier to cite or link to this item: https://doi.org/10.1002/anie.200903971
Title: Chiral guanidinium salt catalyzed enantioselective phospha-mannich reactions
Authors: Fu, X. 
Loh, W.-T.
Zhang, Y.
Chen, T.
Ting, M.
Liu, H.
Wang, J.
Tan, C.-H. 
Keywords: Guanidinium
Mannich reactions
Organocatalysis, phosphinates
Synthetic methods
Issue Date: 21-Sep-2009
Citation: Fu, X., Loh, W.-T., Zhang, Y., Chen, T., Ting, M., Liu, H., Wang, J., Tan, C.-H. (2009-09-21). Chiral guanidinium salt catalyzed enantioselective phospha-mannich reactions. Angewandte Chemie - International Edition 48 (40) : 7387-7390. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.200903971
Abstract: Zero, one, or two? Guanidinium catalyst 1 HBArF 4 (ArF=3,5-(CF3)2C6H3, Bn=benzyl, Ts=4-toluenesulfonyl) was obtained in a single step from a commercially available diamine. By using this catalyst an asymmetric phospha- Mannich reaction has been developed, involving secondary phosphine oxides and H-phosphinates as the P nucleophile. A series of enantiomerically enriched α- amino phosphine oxides (2), α-amino phosphinate, and Hphosphinates containing a P-chiral center were prepared. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
Source Title: Angewandte Chemie - International Edition
URI: http://scholarbank.nus.edu.sg/handle/10635/93301
ISSN: 14337851
DOI: 10.1002/anie.200903971
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