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https://doi.org/10.1002/anie.200903971
| Title: | Chiral guanidinium salt catalyzed enantioselective phospha-mannich reactions | Authors: | Fu, X. Loh, W.-T. Zhang, Y. Chen, T. Ting, M. Liu, H. Wang, J. Tan, C.-H. |
Keywords: | Guanidinium Mannich reactions Organocatalysis, phosphinates Synthetic methods |
Issue Date: | 21-Sep-2009 | Citation: | Fu, X., Loh, W.-T., Zhang, Y., Chen, T., Ting, M., Liu, H., Wang, J., Tan, C.-H. (2009-09-21). Chiral guanidinium salt catalyzed enantioselective phospha-mannich reactions. Angewandte Chemie - International Edition 48 (40) : 7387-7390. ScholarBank@NUS Repository. https://doi.org/10.1002/anie.200903971 | Abstract: | Zero, one, or two? Guanidinium catalyst 1 HBArF 4 (ArF=3,5-(CF3)2C6H3, Bn=benzyl, Ts=4-toluenesulfonyl) was obtained in a single step from a commercially available diamine. By using this catalyst an asymmetric phospha- Mannich reaction has been developed, involving secondary phosphine oxides and H-phosphinates as the P nucleophile. A series of enantiomerically enriched α- amino phosphine oxides (2), α-amino phosphinate, and Hphosphinates containing a P-chiral center were prepared. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA. | Source Title: | Angewandte Chemie - International Edition | URI: | http://scholarbank.nus.edu.sg/handle/10635/93301 | ISSN: | 14337851 | DOI: | 10.1002/anie.200903971 |
| Appears in Collections: | Staff Publications |
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