Please use this identifier to cite or link to this item:
https://doi.org/10.1142/S0192415X08006594
DC Field | Value | |
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dc.title | Characterization of the Anti-Diabetic and Antioxidant Effects of Rehmannia Glutinosa in Streptozotocin-Induced Diabetic Wistar Rats | |
dc.contributor.author | Waisundara, V.Y. | |
dc.contributor.author | Huang, M. | |
dc.contributor.author | Hsu, A. | |
dc.contributor.author | Huang, D. | |
dc.contributor.author | Tan, B.K.-H. | |
dc.date.accessioned | 2014-10-16T08:22:21Z | |
dc.date.available | 2014-10-16T08:22:21Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Waisundara, V.Y., Huang, M., Hsu, A., Huang, D., Tan, B.K.-H. (2008). Characterization of the Anti-Diabetic and Antioxidant Effects of Rehmannia Glutinosa in Streptozotocin-Induced Diabetic Wistar Rats. American Journal of Chinese Medicine 36 (6) : 1083-1104. ScholarBank@NUS Repository. https://doi.org/10.1142/S0192415X08006594 | |
dc.identifier.issn | 0192415X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/93270 | |
dc.description.abstract | This study investigated the effects of Rehmannia glutinosa individually as well as in combination with the oral hypoglycemic agent, metformin in streptozotocin (STZ)-induced diabetic Wistar rats. R. glutinosa ethanolic extract was prepared and the constituents were characterized using fractionation by column chromatography, followed by high performance liquid chromatography-mass spectrometry. STZ (65 mg/kg) was injected intraperitoneally to induce diabetes in Wistar rats. The diabetic rats were divided into the following groups (each n = 6) and received the respective treatments for 30 days: (1) metformin (500 mg/kg), (2) R. glutinosa (200 mg/kg), (3) metformin (500 mg/kg) and R. glutinosa (200 mg/kg) and (4) diabetic control (DC). A reduction in plasma glucose levels caused by the herb was not as significant as metformin compared to the diabetic control (p < 0.05). However, R. glutinosa -treated group showed reductions in plasma C-reactive protein (CRP) levels compared to the diabetic controls (p < 0.05) as well as metformin-treated group (p < 0.05). An enhanced reduction in CRP concentration was observed in the group receiving both herb and metformin compared to metformin-treated group (p < 0.05). Reduction in CRP levels suggests an anti-inflammatory activity of the herb. © 2008 World Scientific Publishing Company. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1142/S0192415X08006594 | |
dc.source | Scopus | |
dc.subject | C-Reactive Protein | |
dc.subject | Diabetes | |
dc.subject | Metformin | |
dc.subject | Traditional Chinese Medicine | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1142/S0192415X08006594 | |
dc.description.sourcetitle | American Journal of Chinese Medicine | |
dc.description.volume | 36 | |
dc.description.issue | 6 | |
dc.description.page | 1083-1104 | |
dc.description.coden | AJCMB | |
dc.identifier.isiut | 000261390000007 | |
Appears in Collections: | Staff Publications |
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