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|Title:||Bioavailability of vitamin D2 from irradiated mushrooms: An in vivo study|
|Citation:||Jasinghe, V.J., Perera, C.O., Barlow, P.J. (2005). Bioavailability of vitamin D2 from irradiated mushrooms: An in vivo study. British Journal of Nutrition 93 (6) : 951-955. ScholarBank@NUS Repository. https://doi.org/10.1079/BJN20051416|
|Abstract:||Vitamin D2 from irradiated edible mushrooms might present a possible dietary source of this vitamin, subject to its bioavailability. Having previously optimized a method for the conversion of ergosterol in mushrooms to vitamin D2, this paper examines the vitamin D-enriched mushrooms (Lentinula edodes) for their bioavailability of the vitamin, using an animal model. Thirty male Wistar rats were fed for 1 week with a diet deficient in vitamin D. After this 1-week period, six rats were randomly selected and killed for analysis of initial bone mineral density, and serum level of 25-hydroxyvitamin D. A group of twelve rats of the test animals received 1 μg of vitamin D2 from irradiated mushrooms for a period of 4 weeks until being killed. The remaining twelve rats were fed un-irradiated mushrooms at the same level to act as controls. At the end of a 4-week period, the mean serum 25-hydroxyvitamin D level of the experimental group was 129.42 (SD 22.00) nmol/1 whereas it was only 6.06 (SD 1.09) nmol/l in the control group. Femur bone mineral density of the experimental group of animals was significantly higher (P|
|Source Title:||British Journal of Nutrition|
|Appears in Collections:||Staff Publications|
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