Please use this identifier to cite or link to this item: https://doi.org/10.1021/ic202530j
Title: Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds
Authors: Nazarov, A.A.
Risse, J.
Ang, W.H. 
Schmitt, F.
Zava, O.
Ruggi, A.
Groessl, M.
Scopelitti, R.
Juillerat-Jeanneret, L.
Hartinger, C.G.
Dyson, P.J.
Issue Date: 19-Mar-2012
Citation: Nazarov, A.A., Risse, J., Ang, W.H., Schmitt, F., Zava, O., Ruggi, A., Groessl, M., Scopelitti, R., Juillerat-Jeanneret, L., Hartinger, C.G., Dyson, P.J. (2012-03-19). Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds. Inorganic Chemistry 51 (6) : 3633-3639. ScholarBank@NUS Repository. https://doi.org/10.1021/ic202530j
Abstract: Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-d-glucofuranoside, were prepared in order to evaluate their anticancer properties compared to the parent compounds and to use them as models for intracellular visualization by fluorescence microscopy. Similar IC 50 values were obtained in cell proliferation assays, and similar levels of uptake and accumulation were also established. The X-ray structure of [{Ru(η 6-C 6H 5CH 2NHCO-anthracene)Cl 2(pta)] is also reported. © 2012 American Chemical Society.
Source Title: Inorganic Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/93112
ISSN: 00201669
DOI: 10.1021/ic202530j
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