Please use this identifier to cite or link to this item:
https://doi.org/10.1002/chem.201400333
DC Field | Value | |
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dc.title | Amine-catalyzed enantioselective 1,3-dipolar cycloadditions of aldehydes to C,N-cyclic azomethine imines | |
dc.contributor.author | Li, W. | |
dc.contributor.author | Jia, Q. | |
dc.contributor.author | Du, Z. | |
dc.contributor.author | Zhang, K. | |
dc.contributor.author | Wang, J. | |
dc.date.accessioned | 2014-10-16T08:20:06Z | |
dc.date.available | 2014-10-16T08:20:06Z | |
dc.date.issued | 2014-04-14 | |
dc.identifier.citation | Li, W., Jia, Q., Du, Z., Zhang, K., Wang, J. (2014-04-14). Amine-catalyzed enantioselective 1,3-dipolar cycloadditions of aldehydes to C,N-cyclic azomethine imines. Chemistry - A European Journal 20 (16) : 4559-4562. ScholarBank@NUS Repository. https://doi.org/10.1002/chem.201400333 | |
dc.identifier.issn | 15213765 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/93074 | |
dc.description.abstract | Amine-catalyzed enantioselective 1,3-dipolar cycloadditions of aldehydes to C,N-cyclic azomethine imines were developed. The reactions between diversely substituted C,N-cyclic azomethine imines and aldehydes proceeded smoothly in the presence of chiral prolinol silyl ether catalyst and gave the C-1-substituted tetrahydroisoquinolines in a highly stereoselective manner. These tetrahydroisoquinolines could be efficiently transformed to several other useful polycyclic frameworks. Go cyclo! An efficient asymmetric 1,3-dipolar cycloaddition reaction catalyzed by a chiral prolinol silyl ether catalyst has been developed (see scheme). Removal of the benzamide group of the intermediates furnished the desired chiral C-1-substituted tetrahydroisoquinolines in high yields with excellent stereoselectivities. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/chem.201400333 | |
dc.source | Scopus | |
dc.subject | asymmetric synthesis | |
dc.subject | cycloadditions | |
dc.subject | enamines | |
dc.subject | heterocycles | |
dc.subject | tetrahydroisoquinoline | |
dc.type | Article | |
dc.contributor.department | CHEMISTRY | |
dc.description.doi | 10.1002/chem.201400333 | |
dc.description.sourcetitle | Chemistry - A European Journal | |
dc.description.volume | 20 | |
dc.description.issue | 16 | |
dc.description.page | 4559-4562 | |
dc.description.coden | CEUJE | |
dc.identifier.isiut | 000334080800008 | |
Appears in Collections: | Staff Publications |
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