Please use this identifier to cite or link to this item: https://doi.org/10.1021/ol300293a
Title: Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids
Authors: Ghosh, S.K.
Somanadhan, B.
Tan, K.S.-W.
Butler, M.S.
Lear, M.J. 
Issue Date: 16-Mar-2012
Citation: Ghosh, S.K., Somanadhan, B., Tan, K.S.-W., Butler, M.S., Lear, M.J. (2012-03-16). Absolute configuration and total synthesis of a novel antimalarial lipopeptide by the de novo preparation of chiral nonproteinogenic amino acids. Organic Letters 14 (6) : 1560-1563. ScholarBank@NUS Repository. https://doi.org/10.1021/ol300293a
Abstract: The absolute configuration (via degradation and Marfey's derivatization studies) and the total synthesis of a novel antimalarial lipid-peptide isolated from Streptomyces sp. (IC 50 = 0.8 μM, Plasmodium falciparum 3D7) is disclosed. To this end, versatile stereocontrolled routes to nonproteinogenic amino acids (via catalytic Mannich, Sharpless methods) and enantiomeric trans fatty acids (via Evans alkylation, Kocienski-Julia olefination) have been developed. © 2012 American Chemical Society.
Source Title: Organic Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/93041
ISSN: 15237060
DOI: 10.1021/ol300293a
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

12
checked on Dec 6, 2018

WEB OF SCIENCETM
Citations

12
checked on Nov 21, 2018

Page view(s)

31
checked on Dec 7, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.