Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0021-9673(97)00912-6
Title: Orthogonal array design experiments for optimizing the separation of various pesticides by cyclodextrin-modified micellar electrokinetic chromatography
Authors: He, Y. 
Kee Lee, H. 
Keywords: Chemometrics
Optimization
Orthogonal array design
Pesticides
Issue Date: 16-Jan-1998
Citation: He, Y., Kee Lee, H. (1998-01-16). Orthogonal array design experiments for optimizing the separation of various pesticides by cyclodextrin-modified micellar electrokinetic chromatography. Journal of Chromatography A 793 (2) : 331-340. ScholarBank@NUS Repository. https://doi.org/10.1016/S0021-9673(97)00912-6
Abstract: The potential of cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) for the separation of complicated environmental samples of pesticides and the applicability of orthogonal array designs (OADs) for the optimization of separation in CD-MEKC were investigated. Six relevant factors were investigated: type and concentration of cyclodextrin, concentration and pH of buffer, and concentration of micelle and organic modifier. In the first experiment, five factors were examined at two levels using an OA16 (215) matrix, by which the effect of each factor was estimated using individual contributions as response function. Based on the results of the first experiment, three most important factors were chosen for further optimization using OA9 (34) matrix to locate more exact levels for each variable. Finally, main-effect curves were used to predict approximate optimum conditions under which adequate separation of 15 pesticides was achieved within 30 min.
Source Title: Journal of Chromatography A
URI: http://scholarbank.nus.edu.sg/handle/10635/91615
ISSN: 00219673
DOI: 10.1016/S0021-9673(97)00912-6
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