Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/91216
DC Field | Value | |
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dc.title | Short- and long-term changes in blood miRNA levels after nanogold injection in rats-potential biomarkers of nanoparticle exposure | |
dc.contributor.author | Chew, W.-S. | |
dc.contributor.author | Poh, K.-W. | |
dc.contributor.author | Siddiqi, N.J. | |
dc.contributor.author | Alhomida, A.S. | |
dc.contributor.author | Yu, L.E. | |
dc.contributor.author | Ong, W.-Y. | |
dc.date.accessioned | 2014-10-09T07:39:24Z | |
dc.date.available | 2014-10-09T07:39:24Z | |
dc.date.issued | 2012-12 | |
dc.identifier.citation | Chew, W.-S., Poh, K.-W., Siddiqi, N.J., Alhomida, A.S., Yu, L.E., Ong, W.-Y. (2012-12). Short- and long-term changes in blood miRNA levels after nanogold injection in rats-potential biomarkers of nanoparticle exposure. Biomarkers 17 (8) : 750-757. ScholarBank@NUS Repository. | |
dc.identifier.issn | 1354750X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/91216 | |
dc.description.abstract | Context: Increased use of engineered nanoparticles may result in exposure of workers and consumers, making them a health concern. Objective: To identify potential blood miRNA biomarkers after intravenous gold nanoparticle (AuNP) exposure. Materials and methods: miRNA microarray analysis was carried out on blood of rats at 1 week and 2 months after injection. Results: Many up- and downregulated miRNAs were detected. Of these, rno-miR-298 was confirmed to be increased at 1 week postinjection by reverse transcription-PCR (RT-PCR). Discussion and conclusion: Blood miRNAs could be useful as biomarkers for exposure to nanoparticles. miR-298 regulates β-amyloid (Aβ) precursor protein-converting enzyme-1 (BACE1) in Alzheimer's disease. © 2012 Informa UK, Ltd. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.3109/1354750X.2012.727030 | |
dc.source | Scopus | |
dc.subject | Blood biomarkers | |
dc.subject | Gold nanoparticles | |
dc.subject | Health effects | |
dc.subject | Intravenous injection | |
dc.subject | MiRNA microarrays | |
dc.type | Article | |
dc.contributor.department | CIVIL & ENVIRONMENTAL ENGINEERING | |
dc.description.sourcetitle | Biomarkers | |
dc.description.volume | 17 | |
dc.description.issue | 8 | |
dc.description.page | 750-757 | |
dc.description.coden | BIOMF | |
dc.identifier.isiut | 000311681100009 | |
Appears in Collections: | Staff Publications |
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