Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/91216
Title: Short- and long-term changes in blood miRNA levels after nanogold injection in rats-potential biomarkers of nanoparticle exposure
Authors: Chew, W.-S.
Poh, K.-W.
Siddiqi, N.J.
Alhomida, A.S.
Yu, L.E. 
Ong, W.-Y.
Keywords: Blood biomarkers
Gold nanoparticles
Health effects
Intravenous injection
MiRNA microarrays
Issue Date: Dec-2012
Citation: Chew, W.-S., Poh, K.-W., Siddiqi, N.J., Alhomida, A.S., Yu, L.E., Ong, W.-Y. (2012-12). Short- and long-term changes in blood miRNA levels after nanogold injection in rats-potential biomarkers of nanoparticle exposure. Biomarkers 17 (8) : 750-757. ScholarBank@NUS Repository.
Abstract: Context: Increased use of engineered nanoparticles may result in exposure of workers and consumers, making them a health concern. Objective: To identify potential blood miRNA biomarkers after intravenous gold nanoparticle (AuNP) exposure. Materials and methods: miRNA microarray analysis was carried out on blood of rats at 1 week and 2 months after injection. Results: Many up- and downregulated miRNAs were detected. Of these, rno-miR-298 was confirmed to be increased at 1 week postinjection by reverse transcription-PCR (RT-PCR). Discussion and conclusion: Blood miRNAs could be useful as biomarkers for exposure to nanoparticles. miR-298 regulates β-amyloid (Aβ) precursor protein-converting enzyme-1 (BACE1) in Alzheimer's disease. © 2012 Informa UK, Ltd.
Source Title: Biomarkers
URI: http://scholarbank.nus.edu.sg/handle/10635/91216
ISSN: 1354750X
Appears in Collections:Staff Publications

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