Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.watres.2011.03.025
Title: Proliferation of antibiotic resistance genes in microbial consortia of sequencing batch reactors (SBRs) upon exposure to trace erythromycin or erythromycin-H2O
Authors: Fan, C.
He, J. 
Keywords: Antibiotics
Biodegradation
Dehydrated erythromycin (ERY-H2O)
Erythromycin (ERY)
Esterase
Resistance
Issue Date: May-2011
Citation: Fan, C., He, J. (2011-05). Proliferation of antibiotic resistance genes in microbial consortia of sequencing batch reactors (SBRs) upon exposure to trace erythromycin or erythromycin-H2O. Water Research 45 (10) : 3098-3106. ScholarBank@NUS Repository. https://doi.org/10.1016/j.watres.2011.03.025
Abstract: A variety of antibiotics and their metabolites at sub-inhibitory level concentrations are suspected to expand resistance genes in the environment. However, knowledge is limited on the causal correlation of trace antibiotics or their metabolites with resistance proliferation. In this study, erythromycin (ERY) resistance genes were screened on microbial consortia of sequencing batch reactors (SBRs) after one year acclimation to ERY (100 μg/L) or dehydrated erythromycin (ERY-H2O, 50 μg/L). The identified esterase gene ereA explains that ERY could be degraded to six products by microbes acclimated to ERY (100 μg/L). However, ERY could not be degraded by microbes acclimated to ERY-H2O (50 μg/L), which may be due to the less proliferated ereA gene. Biodegradation of ERY required the presence of exogenous carbon source (e.g., glucose) and nutrients (e.g., nitrogen, phosphorus) for assimilation, but overdosed ammonium-N (>40 mg/L) inhibited degradation of ERY. Zoogloea, a kind of biofilm formation bacteria, became predominant in the ERY degradation consortia, suggesting that the input of ERY could induce biofilm resistance to antibiotics. Our study highlights that lower μg/L level of ERY or ERY-H2O in the environment encourages expansion of resistance genes in microbes. © 2011 Elsevier Ltd.
Source Title: Water Research
URI: http://scholarbank.nus.edu.sg/handle/10635/91158
ISSN: 00431354
DOI: 10.1016/j.watres.2011.03.025
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

28
checked on Jul 19, 2018

WEB OF SCIENCETM
Citations

22
checked on Jun 25, 2018

Page view(s)

28
checked on Jun 1, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.