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|Title:||Multi-biomarker responses in green mussels exposed to PFCs: Effects at molecular, cellular, and physiological levels|
Emerging organic pollutants
|Citation:||Liu, C., Gin, K.Y.H., Chang, V.W.C. (2014-02). Multi-biomarker responses in green mussels exposed to PFCs: Effects at molecular, cellular, and physiological levels. Environmental Science and Pollution Research 21 (4) : 2785-2794. ScholarBank@NUS Repository. https://doi.org/10.1007/s11356-013-2216-6|
|Abstract:||Perfluorinated chemicals (PFCs) are extremely persistent and have been found extensively in the environment and wildlife. Oceans are the final sink for many persistent organic pollutants (POPs) including PFCs. However, to date, there has been a lack of studies that investigated the environmental consequences of PFCs on marine organisms. To fill in this gap, environmental toxicity of two dominant PFCs, perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA), was examined in a sentinel species, green mussel Perna viridis, using a series of biomarkers corresponding to different biological levels (molecular, cellular, and physiological). Correlations among these biomarkers were also investigated. The results showed that the tested compounds can induce a series adverse effect at different biological levels, including oxidative stress, DNA damage, membrane instability, suppressed filtration rate, and reduced body weight. Correlation analysis revealed that excess production of reactive oxygen species could be the major toxic pathway. An indirect mode of toxic action was also explored where adverse impacts could be secondary effects of PFC exposure. The joint analysis of biomarkers from multiple biological levels resulted in a comprehensive understanding of how PFC exposure can influence the health of organisms. The correlations of these biomarkers also provided a new perspective of the ecological consequences of PFCs. © 2013 Springer-Verlag Berlin Heidelberg.|
|Source Title:||Environmental Science and Pollution Research|
|Appears in Collections:||Staff Publications|
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