Please use this identifier to cite or link to this item: https://doi.org/10.1258/ebm.2010.010021
Title: Nanoparticle-induced pulmonary toxicity
Authors: Li, J.J.
Muralikrishnan, S.
Ng, C.-T. 
Yung, L.-Y.L. 
Bay, B.-H.
Keywords: Lung injury
Nanoparticles
Nanotoxicity
Oxidative stress
Particulate matter
Pulmonary fibrosis
Issue Date: Sep-2010
Source: Li, J.J., Muralikrishnan, S., Ng, C.-T., Yung, L.-Y.L., Bay, B.-H. (2010-09). Nanoparticle-induced pulmonary toxicity. Experimental Biology and Medicine 235 (9) : 1025-1033. ScholarBank@NUS Repository. https://doi.org/10.1258/ebm.2010.010021
Abstract: In recent decades, advances in nanotechnology engineering have given rise to the rapid development of many novel applications in the biomedical field. However, studies into the health and safety of these nanomaterials are still lacking. The main concerns are the adverse effects to health caused by acute or chronic exposure to nanoparticles (NPs), especially in the workplace environment. The lung is one of the main routes of entry for NPs into the body and, hence, a likely site for accumulation of NPs. Once NPs enter the interstitial air spaces and are quickly taken up by alveolar cells, they are likely to induce toxic effects. In this review, we highlight the different aspects of lung toxicity resulting from NP exposure, such as generation of oxidative stress, DNA damage and inflammation leading to fibrosis and pneumoconiosis, and the underlying mechanisms causing pulmonary toxicity. Copyright © 2010 by the Society for Experimental Biology and Medicine.
Source Title: Experimental Biology and Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/90807
ISSN: 15353702
DOI: 10.1258/ebm.2010.010021
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