Please use this identifier to cite or link to this item: https://doi.org/10.1063/1.4811880
Title: Synergistic combination dry powders for inhaled antimicrobial therapy
Authors: Heng, D.
Lee, S.H.
Teo, J.
Ng, W.K.
Chan, H.-K.
Tan, R.B.H. 
Keywords: Antimicrobial
Combinatorial therapy
Dry powder inhaler
Spray drying
Synergy
Issue Date: 2013
Citation: Heng, D., Lee, S.H., Teo, J., Ng, W.K., Chan, H.-K., Tan, R.B.H. (2013). Synergistic combination dry powders for inhaled antimicrobial therapy. AIP Conference Proceedings 1542 : 113-116. ScholarBank@NUS Repository. https://doi.org/10.1063/1.4811880
Abstract: Combination products play an important role in medicine as they offer improved clinical effectiveness, enhanced patient adherence, and reduced administrative costs. In combination antimicrobial therapy, the desired outcome is to extend the antimicrobial spectrum and to achieve a possible synergistic effect. However, adverse antagonistic species may sometimes emerge from such combinations, leading to treatment failure. Therefore, it is crucial to screen the drug candidates for compatibility and possible antagonistic interactions. This work aims to develop a novel synergistic dry powder inhaler (DPI) formulation for antimicrobial combination therapy via the pulmonary route. Binary and ternary combinations were prepared via spray drying on a BUCHI ® Nano Spray Dryer B-90. All powders were within the respirable size range, and were consisted of spherical particles that were slightly corrugated. The powers yielded fine particle fractions (of the loaded dose) of over 40% when dispersed using an Aerolizer® DPI at 60 L/min. Time-kill studies carried out against common respiratory tract pathogenic bacteria Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumonia and Acinetobacter baumannii at 1x the minimum inhibitory concentration (MIC) over 24 hours revealed no antagonistic behavior for both combinations. While the interactions were generally found to be indifferent, a favorable synergistic effect was detected in the binary combination when it was tested against Pseudomonas aeruginosa bacteria. © 2013 AIP Publishing LLC.
Source Title: AIP Conference Proceedings
URI: http://scholarbank.nus.edu.sg/handle/10635/90731
ISBN: 9780735411661
ISSN: 0094243X
DOI: 10.1063/1.4811880
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

1
checked on Sep 20, 2018

WEB OF SCIENCETM
Citations

1
checked on Sep 10, 2018

Page view(s)

53
checked on Jul 20, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.