Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.carbpol.2013.02.046
Title: β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications
Authors: Badruddoza, A.Z.M.
Rahman, M.T.
Ghosh, S.
Hossain, M.Z.
Shi, J. 
Hidajat, K. 
Uddin, M.S.
Keywords: β-Cyclodextrin
Cell targeting
Fluorescent imaging
Hydrophobic drug inclusion
Multifunctional magnetic nanoparticles
Issue Date: 5-Jun-2013
Citation: Badruddoza, A.Z.M., Rahman, M.T., Ghosh, S., Hossain, M.Z., Shi, J., Hidajat, K., Uddin, M.S. (2013-06-05). β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications. Carbohydrate Polymers 95 (1) : 449-457. ScholarBank@NUS Repository. https://doi.org/10.1016/j.carbpol.2013.02.046
Abstract: We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe 3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (β-cyclodextrin). Our preliminary results suggest that such core-shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery. © 2013 Elsevier Ltd.
Source Title: Carbohydrate Polymers
URI: http://scholarbank.nus.edu.sg/handle/10635/90509
ISSN: 01448617
DOI: 10.1016/j.carbpol.2013.02.046
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