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|Title:||β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications|
Hydrophobic drug inclusion
Multifunctional magnetic nanoparticles
|Source:||Badruddoza, A.Z.M., Rahman, M.T., Ghosh, S., Hossain, M.Z., Shi, J., Hidajat, K., Uddin, M.S. (2013-06-05). β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications. Carbohydrate Polymers 95 (1) : 449-457. ScholarBank@NUS Repository. https://doi.org/10.1016/j.carbpol.2013.02.046|
|Abstract:||We present synthesis of highly uniform magnetic nanocomposite material possessing an assortment of important functionalities: magnetism, luminescence, cell-targeting, and hydrophobic drug delivery. Magnetic particle Fe 3O4 is encapsulated within a shell of SiO2 that ensures biocompatibility of the nanocomposite as well as act as a host for fluorescent dye (FITC), cancer-targeting ligand (folic acid), and a hydrophobic drug storage-delivering vehicle (β-cyclodextrin). Our preliminary results suggest that such core-shell nanocomposite can be a smart theranostic candidate for simultaneous fluorescence imaging, magnetic manipulation, cancer cell-targeting and hydrophobic drug delivery. © 2013 Elsevier Ltd.|
|Source Title:||Carbohydrate Polymers|
|Appears in Collections:||Staff Publications|
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