Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijpharm.2011.09.045
Title: Vitamin e TPGS coated liposomes enhanced cellular uptake and cytotoxicity of docetaxel in brain cancer cells
Authors: Muthu, M.S.
Kulkarni, S.A. 
Xiong, J.
Feng, S.-S. 
Keywords: Cancer nanotechnology
Molecular biomaterials
Nanomedicine
PEGylation
Stealth liposomes
Taxotere®
Issue Date: 15-Dec-2011
Citation: Muthu, M.S., Kulkarni, S.A., Xiong, J., Feng, S.-S. (2011-12-15). Vitamin e TPGS coated liposomes enhanced cellular uptake and cytotoxicity of docetaxel in brain cancer cells. International Journal of Pharmaceutics 421 (2) : 332-340. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpharm.2011.09.045
Abstract: The aim of this work was to develop a drug delivery system of liposomes, which are coated with d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS), a PEGylated vitamin E, with docetaxel as a model drug for enhanced treatment of brain tumour in comparison with the nude liposomes as well as with the so-called stealth liposomes, i.e. those coated with polyethylene glycol (PEG), which have been intensive investigated in the literature. Docetaxel or coumarin-6 loaded liposomes were prepared by the solvent injection method and characterized for their particle size, polydispersity, zeta potential and drug encapsulation efficiency. C6 glioma cells were employed as an in vitro model to access cellular uptake and cytotoxicity of the drug or coumarin-6 loaded liposomes. The particle size of the PEG or TPGS coated liposomes was ranged between 126 and 191 nm. High-resolution field-emission transmission electron microscopy (FETEM) confirmed the coating of TPGS on the liposomes. The IC50 value, which is the drug concentration needed to kill 50% cells in a designated time period, was found to be 37.04 ± 1.05, 31.04 ± 0.75, 7.70 ± 0.22, and 5.93 ± 0.57 μg/ml for the commercial Taxotere ®, the nude, PEG coated and TPGS coated liposomes, respectively after 24 h culture with C6 glioma cells. The TPGS coated liposomes showed great advantages in vitro than the PEG coated liposomes. © 2011 Elsevier B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/90483
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2011.09.045
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

91
checked on May 22, 2018

WEB OF SCIENCETM
Citations

80
checked on May 15, 2018

Page view(s)

25
checked on Mar 11, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.