Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.biomaterials.2013.01.009
DC Field | Value | |
---|---|---|
dc.title | Targeted co-delivery of docetaxel and siPlk1 by herceptin-conjugated vitamin E TPGS based immunomicelles | |
dc.contributor.author | Zhao, J. | |
dc.contributor.author | Mi, Y. | |
dc.contributor.author | Feng, S.-S. | |
dc.date.accessioned | 2014-10-09T07:03:40Z | |
dc.date.available | 2014-10-09T07:03:40Z | |
dc.date.issued | 2013-04 | |
dc.identifier.citation | Zhao, J., Mi, Y., Feng, S.-S. (2013-04). Targeted co-delivery of docetaxel and siPlk1 by herceptin-conjugated vitamin E TPGS based immunomicelles. Biomaterials 34 (13) : 3411-3421. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2013.01.009 | |
dc.identifier.issn | 01429612 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/90299 | |
dc.description.abstract | We developed a drug delivery system of herceptin-conjugated micelles, which consist of vitamin E TPGS and TPGS-siRNA conjugates, for targeted co-delivery of docetaxel and polo-like kinase 1 siRNA to achieve synergistic effects between the anticancer drug and the small interfering RNA responsible for multidrug resistance. The TPGS-siRNA conjugate is made through disulfide bond that could enable a pH-sensitive intracellular release. The load ratio between siPlk1 and docetaxel could be controlled by adjusting the siPlk1-TPGS to TPGS ratio as well as the drug to polymer ratio. NIH3T3, MCF7, and SK-BR-3 cell lines, which are of low, moderate and high HER2 overexpression, were employed to obtain proof-of-concept experimental results for the advantages of such a design. It has been shown that the IC50, which is the drug concentration needed to kill 50% of the cancer cells in a designated time period, was 1.72, 0.042, 0.0032 and 0.000671 μg/mL for SK-BR-3 cells after 24 h treatment by Taxotere®, and docetaxel formulated in the TPGS micelles, the TPGS-siPlk1/TPGS micelles and the herceptin-conjugated TPGS-siPlk1/TPGS micelles, respectively. © 2013 Elsevier Ltd. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biomaterials.2013.01.009 | |
dc.source | Scopus | |
dc.subject | Anticancer drugs | |
dc.subject | Biodegradable polymers | |
dc.subject | Cancer nanotechnology | |
dc.subject | Molecular biomaterials | |
dc.subject | Nanomedicine | |
dc.subject | SiRNA | |
dc.type | Article | |
dc.contributor.department | CHEMICAL & BIOMOLECULAR ENGINEERING | |
dc.description.doi | 10.1016/j.biomaterials.2013.01.009 | |
dc.description.sourcetitle | Biomaterials | |
dc.description.volume | 34 | |
dc.description.issue | 13 | |
dc.description.page | 3411-3421 | |
dc.description.coden | BIMAD | |
dc.identifier.isiut | 000316770100025 | |
Appears in Collections: | Staff Publications |
Show simple item record
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.