Please use this identifier to cite or link to this item: https://doi.org/10.1002/marc.200800771
Title: Synthesis of folic acid functionalized PLLA-b- PPEGMA nanoparticles for cancer cell targeting
Authors: Hu, F.
Neoh, K.G. 
Kang, E.-T. 
Keywords: Atom transfer radical polymerization (ATRP)
Folic acid
Nanoparticles
Poly(ethylene glycol)
Targeted delivery
Issue Date: 20-Apr-2009
Citation: Hu, F., Neoh, K.G., Kang, E.-T. (2009-04-20). Synthesis of folic acid functionalized PLLA-b- PPEGMA nanoparticles for cancer cell targeting. Macromolecular Rapid Communications 30 (8) : 609-614. ScholarBank@NUS Repository. https://doi.org/10.1002/marc.200800771
Abstract: Poly(L-lactic acid)-block-poly(poly(ethylene glycol) monomethacrylate) (PLLA-b-PPEGMA) has been prepared by the ring-opening polymerization of lactide with a double-headed initiator, 2- hydroxyethyl 2′-methyl-2′- bromopropionate (HMBP), followed by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate (PEGMA). PLLA-b-PPEGMA nanoparticles with encapsulated Fe3O4 are prepared by a solvent evaporation/extraction technique, and then further functionalized with folic acid, a cancer targeting ligand. Our results show that such functionalized PLLA-b-PPEGMA nanoparticles have good potential as carriers for targeted drug delivery in cancer treatment. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Source Title: Macromolecular Rapid Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/90273
ISSN: 10221336
DOI: 10.1002/marc.200800771
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