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|Title:||Synthesis of folic acid functionalized PLLA-b- PPEGMA nanoparticles for cancer cell targeting|
|Keywords:||Atom transfer radical polymerization (ATRP)|
|Citation:||Hu, F., Neoh, K.G., Kang, E.-T. (2009-04-20). Synthesis of folic acid functionalized PLLA-b- PPEGMA nanoparticles for cancer cell targeting. Macromolecular Rapid Communications 30 (8) : 609-614. ScholarBank@NUS Repository. https://doi.org/10.1002/marc.200800771|
|Abstract:||Poly(L-lactic acid)-block-poly(poly(ethylene glycol) monomethacrylate) (PLLA-b-PPEGMA) has been prepared by the ring-opening polymerization of lactide with a double-headed initiator, 2- hydroxyethyl 2′-methyl-2′- bromopropionate (HMBP), followed by atom transfer radical polymerization (ATRP) of poly(ethylene glycol) monomethacrylate (PEGMA). PLLA-b-PPEGMA nanoparticles with encapsulated Fe3O4 are prepared by a solvent evaporation/extraction technique, and then further functionalized with folic acid, a cancer targeting ligand. Our results show that such functionalized PLLA-b-PPEGMA nanoparticles have good potential as carriers for targeted drug delivery in cancer treatment. © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.|
|Source Title:||Macromolecular Rapid Communications|
|Appears in Collections:||Staff Publications|
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