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|Title:||Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles|
Magnetic drug targeting
|Citation:||Hu, F.X., Neoh, K.G., Kang, E.T. (2006-11). Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles. Biomaterials 27 (33) : 5725-5733. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2006.07.014|
|Abstract:||The present study deals with the synthesis and characterization of tamoxifen-loaded magnetite/poly(l-lactic acid) composite nanoparticles (TMCN), and their in vitro anti-cancer activity against MCF-7 breast cancer cells. The composite nanoparticles with an average size of ∼200 nm, were synthesized via a solvent evaporation/extraction technique in an oil/water emulsion. The superparamagnetic property (saturation magnetization value of ∼7 emu/g) of the TMCN is provided by Fe3O4 nanoparticles of ∼6 nm encapsulated in the poly(l-lactic acid) matrix. The encapsulation efficiency of the Fe3O4 and tamoxifen as a function of the concentration in the organic phase was investigated. The uptake of TMCN and tamoxifen by MCF-7 was estimated from the intracellular iron concentration. After 4 h incubation of MCF-7 with TMCN, significant changes in the cell morphology were discernible from phase contrast microscopy. Cytotoxicity assay shows that while the Fe3O4-loaded poly(l-lactic acid) composite nanoparticles exhibit no significant cytotoxicity against MCF-7, ∼80% of the these cells were killed after incubation for 4 days with TMCN. © 2006 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Staff Publications|
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