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Title: Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles
Authors: Hu, F.X.
Neoh, K.G. 
Kang, E.T. 
Keywords: Composite nanoparticles
Controlled release
Magnetic drug targeting
Issue Date: Nov-2006
Citation: Hu, F.X., Neoh, K.G., Kang, E.T. (2006-11). Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles. Biomaterials 27 (33) : 5725-5733. ScholarBank@NUS Repository.
Abstract: The present study deals with the synthesis and characterization of tamoxifen-loaded magnetite/poly(l-lactic acid) composite nanoparticles (TMCN), and their in vitro anti-cancer activity against MCF-7 breast cancer cells. The composite nanoparticles with an average size of ∼200 nm, were synthesized via a solvent evaporation/extraction technique in an oil/water emulsion. The superparamagnetic property (saturation magnetization value of ∼7 emu/g) of the TMCN is provided by Fe3O4 nanoparticles of ∼6 nm encapsulated in the poly(l-lactic acid) matrix. The encapsulation efficiency of the Fe3O4 and tamoxifen as a function of the concentration in the organic phase was investigated. The uptake of TMCN and tamoxifen by MCF-7 was estimated from the intracellular iron concentration. After 4 h incubation of MCF-7 with TMCN, significant changes in the cell morphology were discernible from phase contrast microscopy. Cytotoxicity assay shows that while the Fe3O4-loaded poly(l-lactic acid) composite nanoparticles exhibit no significant cytotoxicity against MCF-7, ∼80% of the these cells were killed after incubation for 4 days with TMCN. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2006.07.014
Appears in Collections:Staff Publications

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