Please use this identifier to cite or link to this item:
|Title:||Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles|
Magnetic drug targeting
|Citation:||Hu, F.X., Neoh, K.G., Kang, E.T. (2006-11). Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles. Biomaterials 27 (33) : 5725-5733. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2006.07.014|
|Abstract:||The present study deals with the synthesis and characterization of tamoxifen-loaded magnetite/poly(l-lactic acid) composite nanoparticles (TMCN), and their in vitro anti-cancer activity against MCF-7 breast cancer cells. The composite nanoparticles with an average size of ∼200 nm, were synthesized via a solvent evaporation/extraction technique in an oil/water emulsion. The superparamagnetic property (saturation magnetization value of ∼7 emu/g) of the TMCN is provided by Fe3O4 nanoparticles of ∼6 nm encapsulated in the poly(l-lactic acid) matrix. The encapsulation efficiency of the Fe3O4 and tamoxifen as a function of the concentration in the organic phase was investigated. The uptake of TMCN and tamoxifen by MCF-7 was estimated from the intracellular iron concentration. After 4 h incubation of MCF-7 with TMCN, significant changes in the cell morphology were discernible from phase contrast microscopy. Cytotoxicity assay shows that while the Fe3O4-loaded poly(l-lactic acid) composite nanoparticles exhibit no significant cytotoxicity against MCF-7, ∼80% of the these cells were killed after incubation for 4 days with TMCN. © 2006 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jun 22, 2018
WEB OF SCIENCETM
checked on May 21, 2018
checked on Jun 8, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.