Please use this identifier to cite or link to this item:
|Title:||Synthesis and characterization of elastic star shape-memory polymers as self-expandable drug-eluting stents|
|Citation:||Xue, L., Dai, S., Li, Z. (2012-04-21). Synthesis and characterization of elastic star shape-memory polymers as self-expandable drug-eluting stents. Journal of Materials Chemistry 22 (15) : 7403-7411. ScholarBank@NUS Repository. https://doi.org/10.1039/c2jm15918j|
|Abstract:||Elastic shape-memory polymers as self-expendable polymeric drug-eluting stents are developed for the first time, with good mechanical properties, fast self-expansion, and sustained drug release. Novel star block co-polymer PCTOPDs containing hyperbranched poly(ε-caprolactone) (PCL) switching segment and poly(2-oxepane-1,5-dione) (POPD) hard segment were synthesized in high yield and characterized by NMR, GPC, DSC, tensile test and cyclic thermomechanical tensile test. PCTOPD containing 15-27 wt% POPD (PCTOPD-15-27) are found to be non-cytotoxic thermoplastic elastomers (T m of 39-40 and 120-129 °C, ε b of 908-1060%, σ m of 12-20 MPa, and E of 60-91 MPa) with good shape-memory properties at 40 °C (R f of 95-97%, R r of 97-99%, and shape recovery time of 35 s). The stent made from PCTOPD-27 gives nearly full self-expansion at 37 °C within 45 s. The collapse pressure at a compressive strain of 30% is 1.7 bar. A stent containing 3.0 wt% paclitaxel releases 42% drug linearly in the first 9 days and 67% drug in 30 days with a slower but nearly linear release for the period of 10-30 days. The developed SMP-based drug-eluting stents might be useful in biomedical application such as the treatment of coronary artery disease. © 2012 The Royal Society of Chemistry.|
|Source Title:||Journal of Materials Chemistry|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Jul 17, 2018
WEB OF SCIENCETM
checked on Jun 27, 2018
checked on Jul 6, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.