Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2tb00273f
Title: Surface-functionalizable membranes of polycaprolactone-click-hyperbranched polyglycerol copolymers from combined atom transfer radical polymerization, ring-opening polymerization and click chemistry
Authors: Cai, T.
Li, M.
Neoh, K.-G. 
Kang, E.-T. 
Issue Date: 7-Mar-2013
Citation: Cai, T., Li, M., Neoh, K.-G., Kang, E.-T. (2013-03-07). Surface-functionalizable membranes of polycaprolactone-click-hyperbranched polyglycerol copolymers from combined atom transfer radical polymerization, ring-opening polymerization and click chemistry. Journal of Materials Chemistry B 1 (9) : 1304-1315. ScholarBank@NUS Repository. https://doi.org/10.1039/c2tb00273f
Abstract: Hyperbranched polyglycerols containing terminal alkyne and alkyl bromide groups (CHC-HPG-Br) were first synthesized via propargyl alcohol-initiated ring-opening polymerization (ROP) of glycidol, followed by reaction of 2-bromoisobutyryl bromide (BIBB) with the hydroxyl groups to introduce the atom transfer radical polymerization (ATRP) initiators on HPG. Hydrophobic azido-terminated poly(ε-caprolactone) (PCL-N3), prepared a priori via 2-azidoethanol-initiated ROP of ε-caprolactone, was then coupled to the CHC-HPG-Br polymer through a Cu(i)-catalyzed alkyne-azide click reaction. The resultant linear-hyperbranched PCL-click-HPG copolymers were cast by phase inversion in an aqueous medium into microporous membranes of well-defined and uniform pores. Not only could the HPG contents in the PCL-click-HPG copolymers be used to control the pore size and porosity of the resulting membranes, but also the alkyl halide chain-ends of HPG allowed the subsequent functionalization of membrane and pore surfaces. The PCL-click-HPG-b-PMPC membrane was prepared via surface-initiated ATRP of zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) from the PCL-click-HPG membrane and pore surfaces. The PCL-click-HPG-b-PMPC membranes exhibit good antifouling and antibacterial adhesion properties with negligible cytotoxicity effects, making the membranes potentially useful for biomaterials and biomedical applications. © 2013 The Royal Society of Chemistry.
Source Title: Journal of Materials Chemistry B
URI: http://scholarbank.nus.edu.sg/handle/10635/90241
ISSN: 20507518
DOI: 10.1039/c2tb00273f
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