Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10870-011-0147-y
Title: Structural, spectroscopic and thermal analysis of cocrystals of carbamazepine and piracetam with hydroquinone
Authors: Aitipamula, S.
Chow, P.S.
Tan, R.B.H. 
Keywords: Carbamazepine
Cocrystal
Crystal structure
Hydroquinone
Infrared
Piracetam
Synthon
Issue Date: Nov-2011
Source: Aitipamula, S., Chow, P.S., Tan, R.B.H. (2011-11). Structural, spectroscopic and thermal analysis of cocrystals of carbamazepine and piracetam with hydroquinone. Journal of Chemical Crystallography 41 (11) : 1604-1611. ScholarBank@NUS Repository. https://doi.org/10.1007/s10870-011-0147-y
Abstract: Cocrystals of two important active pharmaceutical ingredients, carbamazepine and piracetam, with hydroquinone are reported. Cocrystal formation between the selected APIs and hydroquinone is investigated with the aid of solid-state grinding methods. Both the crystal structures belong to the triclinic, P 1 space group, with the cocrystal involving carbamazepine and hydroquinone having the unit cell parameters a = 6.9725 (14) Å, b = 8.8175 (18) Å, c = 15.083 (3) Å, α = 106.96 (3)°, β = 92.16 (3)°, γ = 103.23 (3)°, V = 858.0 (4) Å3 and Z = 2; and the cocrystal involving piracetam and hydroquinone has the unit cell parameters a = 6.4909 (13) Å, b = 6.5410 (13) Å, c = 11.612 (2) Å, α = 103.92 (3)°, β = 104.53 (3)°, γ = 91.06 (3)°, V = 461.59 (18) Å3 and Z = 2. Analysis of the cocrystals revealed that they are sustained by an alcohol-carboxamide heterosynthon. In addition, the cocrystal of carbamazepine and hydroquinone features an amide-alcohol heterosynthon and an alcohol-alcohol homosynthon. The cocrystal of piracetam and hydroquinone features an amide-amide dimer synthon. Cocrystal formation was evidenced from the shifts in the vibrational frequencies corresponding to the functional groups present on the cocrystal components. © 2011 Springer Science+Business Media, LLC.
Source Title: Journal of Chemical Crystallography
URI: http://scholarbank.nus.edu.sg/handle/10635/90214
ISSN: 10741542
DOI: 10.1007/s10870-011-0147-y
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