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Title: Sonochemical synthesis of (3-aminopropyl)triethoxysilane-modified monodispersed silica nanoparticles for protein immobilization
Authors: Shen, S.-C.
Ng, W.K.
Chia, L.
Dong, Y.-C.
Tan, R.B.H. 
Keywords: A. Interfaces
A. Nanostructures
B. Chemical synthesis
D. Surface properties
Issue Date: Oct-2011
Source: Shen, S.-C., Ng, W.K., Chia, L., Dong, Y.-C., Tan, R.B.H. (2011-10). Sonochemical synthesis of (3-aminopropyl)triethoxysilane-modified monodispersed silica nanoparticles for protein immobilization. Materials Research Bulletin 46 (10) : 1665-1669. ScholarBank@NUS Repository.
Abstract: 3-Aminopropyltriethoxysilane modified monodispersed silica nanoparticles were synthesized by a rapid sonochemical co-condensation synthesis procedure. The chemical nature of surface organic modifier on the obtained modified silica nanoparticle was characterized by 13C and 29Si MAS Nuclear Magnetic Resonance (NMR) spectroscopies, Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA)- differential scanning calorimetry (DSC). Due to the strengthened positive surface charge of the silica nanoparticles by the modification with aminopropyl groups, the capability for bovine serum albumin (BSA) adsorption was significantly increased as compared with bare silica nanoparticles. 80 mg/g BSA was adsorbed on modified silica nanoparticles, whereas only 20 mg/g BSA could be loaded on pure silica nanoparticles. The enhanced positive surface charge repelled proteins with net positive charge and the modified silica nanoparticles exhibited negligible adsorption of lysozyme, thus a selective adsorption of proteins could be achieved. © 2011 Elsevier Ltd. All rights reserved.
Source Title: Materials Research Bulletin
ISSN: 00255408
DOI: 10.1016/j.materresbull.2011.06.004
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