Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2007.08.039
Title: Solvent-free atom transfer radical polymerization for the preparation of poly(poly(ethyleneglycol) monomethacrylate)-grafted Fe3O4 nanoparticles: Synthesis, characterization and cellular uptake
Authors: Fan, Q.-L.
Neoh, K.-G. 
Kang, E.-T. 
Shuter, B.
Wang, S.-C.
Keywords: ATRP
Magnetic nanoparticle
MRI
PEGMA
Solvent-free
Issue Date: Dec-2007
Citation: Fan, Q.-L., Neoh, K.-G., Kang, E.-T., Shuter, B., Wang, S.-C. (2007-12). Solvent-free atom transfer radical polymerization for the preparation of poly(poly(ethyleneglycol) monomethacrylate)-grafted Fe3O4 nanoparticles: Synthesis, characterization and cellular uptake. Biomaterials 28 (36) : 5426-5436. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2007.08.039
Abstract: Poly(poly(ethyleneglycol) monomethacrylate) (P(PEGMA))-grafted magnetic nanoparticles (MNPs) were successfully prepared via a solvent-free atom transfer radical polymerization (ATRP) method. The macroinitiators were immobilized on the surface of 6.4±0.8 nm Fe3O4 nanoparticles via effective ligand exchange of oleic acid with 3-chloropropionic acid (CPA), which rendered the nanoparticles soluble in the PEGMA monomer. The so-obtained P(PEGMA)-grafted MNPs have a uniform hydrodynamic particle size of 36.0±1.2 nm. The successful grafting of P(PEGMA) on the MNP surface was ascertained from FTIR and XPS analyses. The uptake of the MNPs by macrophage cells is reduced by two-orders of magnitude to
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/90188
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2007.08.039
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