Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.fluid.2005.08.004
Title: Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures
Authors: Huang, Z.
Chiew, Y.C.
Lu, W.-D.
Kawi, S. 
Keywords: Alcohol
Aspirin
Peng-Robinson EOS
Solubility enhancement
Supercritical CO2
Issue Date: 25-Oct-2005
Source: Huang, Z., Chiew, Y.C., Lu, W.-D., Kawi, S. (2005-10-25). Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures. Fluid Phase Equilibria 237 (1-2) : 9-15. ScholarBank@NUS Repository. https://doi.org/10.1016/j.fluid.2005.08.004
Abstract: The introduction of polar cosolvents is not only able to dramatically increase solubilities of polar organic solids in supercritical CO2 but also can make supercritical CO2 extraction more attractive in various separation applications. In this study, we have measured the solubility of aspirin in methanol-modified and ethanol-modified supercritical CO 2 by means of a dynamic saturation method. Experimental results show the aspirin solubility can be greatly enhanced up to 14 times by introducing 3.0 mol% methanol or ethanol. This enhancement, as believed, is mainly attributed to the strong attractive molecular interactions between the polar cosolvent and the polar solute. The aspirin ternary solubility data are fairly well described by using the Peng-Robinson equation of state model with an AARD ranging from 14 to 23%. © 2005 Elsevier B.V. All rights reserved.
Source Title: Fluid Phase Equilibria
URI: http://scholarbank.nus.edu.sg/handle/10635/90178
ISSN: 03783812
DOI: 10.1016/j.fluid.2005.08.004
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