Please use this identifier to cite or link to this item:
Title: Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures
Authors: Huang, Z.
Chiew, Y.C.
Lu, W.-D.
Kawi, S. 
Keywords: Alcohol
Peng-Robinson EOS
Solubility enhancement
Supercritical CO2
Issue Date: 25-Oct-2005
Citation: Huang, Z., Chiew, Y.C., Lu, W.-D., Kawi, S. (2005-10-25). Solubility of aspirin in supercritical carbon dioxide/alcohol mixtures. Fluid Phase Equilibria 237 (1-2) : 9-15. ScholarBank@NUS Repository.
Abstract: The introduction of polar cosolvents is not only able to dramatically increase solubilities of polar organic solids in supercritical CO2 but also can make supercritical CO2 extraction more attractive in various separation applications. In this study, we have measured the solubility of aspirin in methanol-modified and ethanol-modified supercritical CO 2 by means of a dynamic saturation method. Experimental results show the aspirin solubility can be greatly enhanced up to 14 times by introducing 3.0 mol% methanol or ethanol. This enhancement, as believed, is mainly attributed to the strong attractive molecular interactions between the polar cosolvent and the polar solute. The aspirin ternary solubility data are fairly well described by using the Peng-Robinson equation of state model with an AARD ranging from 14 to 23%. © 2005 Elsevier B.V. All rights reserved.
Source Title: Fluid Phase Equilibria
ISSN: 03783812
DOI: 10.1016/j.fluid.2005.08.004
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Sep 20, 2018


checked on Sep 10, 2018

Page view(s)

checked on Aug 31, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.