Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.colsurfb.2012.01.018
Title: Solid lipid nanoparticles: Continuous and potential large-scale nanoprecipitation production in static mixers
Authors: Dong, Y.
Ng, W.K.
Shen, S.
Kim, S.
Tan, R.B.H. 
Keywords: Controlled release
Nanoprecipitation
Solid lipid nanoparticles
Static mixers
Issue Date: 1-Jun-2012
Citation: Dong, Y., Ng, W.K., Shen, S., Kim, S., Tan, R.B.H. (2012-06-01). Solid lipid nanoparticles: Continuous and potential large-scale nanoprecipitation production in static mixers. Colloids and Surfaces B: Biointerfaces 94 : 68-72. ScholarBank@NUS Repository. https://doi.org/10.1016/j.colsurfb.2012.01.018
Abstract: This work aimed at developing continuous and scalable nanoprecipitation synthesis of solid lipid nanoparticles (SLN) by mixing lipids acetonic solution with water using static mixers. The developed platform exhibited good control over the nanoprecipitation process and enabled the production of SLN below 200. nm at a throughput of 37.5-150. g/h (for 25. mg/ml lipid solution at a flow rate of 25-100. ml/min). Among the several process parameters investigated, the lipid concentration played primary role in influencing the size of the SLN and higher lipid concentration resulted in relatively larger particles. Fenofibrate, a model drug, has been successfully loaded into the SLN. Our work demonstrates the potential of applying static mixing-nanoprecipitation for continuous and large scale production of SLN. © 2012 Elsevier B.V.
Source Title: Colloids and Surfaces B: Biointerfaces
URI: http://scholarbank.nus.edu.sg/handle/10635/90171
ISSN: 09277765
DOI: 10.1016/j.colsurfb.2012.01.018
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