Smart nanofibers with a photoresponsive surface for controlled release
Fu, G.-D. Xu, L.-Q. Yao, F. Li, G.-L. Kang, E.-T.
Fu, G.-D.
Xu, L.-Q.
Yao, F.
Li, G.-L.
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Alternative Title
Abstract
A novel photocontrolled 'ON-OFF' release system for the α-cyclodextrin-5-fluorouracial (α-CD-5FU) prodrug, based on host-guest interaction on the photoresponsive and cross-linked nanofiber surface, was demonstrated. The nanofibers with a stimuli-responsive surface were electrospun from the block copolymer prepared via controlled radical polymerization, followed by surface modification via 'Click Chemistry', and loading of the prodrug via host-guest interaction. © 2009 American Chemical Society.
Keywords
controlled release, cyclodextrin prodrug, host-guest interaction, nanofibers, photoresponsive
Source Title
ACS Applied Materials and Interfaces
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Series/Report No.
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Date
2009-11-25
DOI
Type
Article