Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biomaterials.2008.08.043
Title: Silk-functionalized titanium surfaces for enhancing osteoblast functions and reducing bacterial adhesion
Authors: Zhang, F.
Zhang, Z.
Zhu, X.
Kang, E.-T. 
Neoh, K.-G. 
Keywords: Bacterial adhesion
Methacrylic acid sodium salt
Osteoblast
Silk
Surface-initiated ATRP
Titanium
Issue Date: Dec-2008
Source: Zhang, F., Zhang, Z., Zhu, X., Kang, E.-T., Neoh, K.-G. (2008-12). Silk-functionalized titanium surfaces for enhancing osteoblast functions and reducing bacterial adhesion. Biomaterials 29 (36) : 4751-4759. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biomaterials.2008.08.043
Abstract: It would be ideal to have implants which can simultaneously inhibit bacterial adhesion and promote osteoblast functions. In this work, titanium surfaces were modified with poly(methacrylic acid) (P(MAA)) followed by immobilization of silk sericin. Firstly a trichlorosilane coupling agent, which is an atom transfer radical polymerization (ATRP) initiator, was immobilized on the oxidized titanium surface to facilitate the surface-initiated ATRP of methacrylic acid sodium salt (MAAS). The pendant carboxyl end groups of the grafted and partially protonated MAA chains were subsequently coupled with silk sericin via carbodiimide chemistry. The functionalized Ti surfaces were characterized by X-ray photoelectron spectroscopy, and assayed for osteoblast cell functions and bacterial adhesion. The covalently immobilized MAA brushes significantly reduce the adhesion of the two bacterial strains (Staphylococcus aureus and Staphylococcus epidermidis) tested. The silk sericin-immobilized surfaces, at the same time, promote osteoblast cells' adhesion, proliferation, and alkaline phosphatase activity. Thus, the P(MAA) and silk sericin functionalized Ti surfaces have potential applications combating biomaterial-centered infection and promoting osseointegration. © 2008 Elsevier Ltd. All rights reserved.
Source Title: Biomaterials
URI: http://scholarbank.nus.edu.sg/handle/10635/90139
ISSN: 01429612
DOI: 10.1016/j.biomaterials.2008.08.043
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

110
checked on Feb 21, 2018

WEB OF SCIENCETM
Citations

93
checked on Dec 11, 2017

Page view(s)

28
checked on Feb 17, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.