Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/90111
Title: Self-assembly of cholesterol DNA at liquid crystal/aqueous interface and its application for DNA detection
Authors: Lai, S.L.
Hartono, D. 
Yang, K.-L. 
Issue Date: 2009
Citation: Lai, S.L., Hartono, D., Yang, K.-L. (2009). Self-assembly of cholesterol DNA at liquid crystal/aqueous interface and its application for DNA detection. Applied Physics Letters 95 (15) : -. ScholarBank@NUS Repository.
Abstract: In this letter, we report a strategy of detecting the DNA targets by using a thin layer of self-assembled cholesterol-labeled DNA probes at the liquid crystal (LC)/aqueous interface. When the system is exposed to 51 μg/ml of complementary DNA targets, the optical appearance of LC shows a continuous change from dark to bright under the crossed polars within 15 min. No obvious change can be observed when the system is exposed to one or two base-pair mismatch DNA targets. This system provides a principle for label-free and real-time detection of DNA targets without any fluorescent labeling. © 2009 American Institute of Physics.
Source Title: Applied Physics Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/90111
ISSN: 00036951
Appears in Collections:Staff Publications

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