Please use this identifier to cite or link to this item:
|Title:||Seeding and constant-supersaturation control by ATR-FTIR in anti-solvent crystallization|
|Citation:||Yu, Z.Q., Chow, P.S., Tan, R.B.H. (2006-07). Seeding and constant-supersaturation control by ATR-FTIR in anti-solvent crystallization. Organic Process Research and Development 10 (4) : 717-722. ScholarBank@NUS Repository.|
|Abstract:||The strategy for seeding and supersaturation control can play a critical role in defining the purity and particle size distribution of crystal products. Previous research has demonstrated that operation of crystallizers at constant supersaturation by feedback control is attractive due to its simplicity and resistance to operating disturbances. In this study, the effects of seed loading and seed size distribution were investigated for anti-solvent crystallization of paracetamol from a water-acetone mixture operated at constant supersaturation. A seeding strategy based on a simple mass balance equation provided a good starting point for the refinement of particle size distribution and adjustment of batch time in different circumstances to obtain a target average crystal size with narrow size distribution. © 2006 American Chemical Society.|
|Source Title:||Organic Process Research and Development|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 8, 2018
WEB OF SCIENCETM
checked on Dec 31, 2018
checked on Dec 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.