Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2sm25368b
Title: Preparation of stimuli-responsive hydrogel networks with threaded β-cyclodextrin end-capped chains via combination of controlled radical polymerization and click chemistry
Authors: Cai, T.
Yang, W.J.
Zhang, Z.
Zhu, X.
Neoh, K.-G. 
Kang, E.-T. 
Issue Date: 28-May-2012
Citation: Cai, T., Yang, W.J., Zhang, Z., Zhu, X., Neoh, K.-G., Kang, E.-T. (2012-05-28). Preparation of stimuli-responsive hydrogel networks with threaded β-cyclodextrin end-capped chains via combination of controlled radical polymerization and click chemistry. Soft Matter 8 (20) : 5612-5620. ScholarBank@NUS Repository. https://doi.org/10.1039/c2sm25368b
Abstract: Hydrogel networks of poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEG-b-PPG-b-PEG primary network), with threaded sliding β-cyclodextrin-capped poly(2-(methacryloyloxy)ethyl succinate) (βCD-capped-PMES) chains, are described. The hydrogels were prepared by UV-initiated thiol-ene click reaction of the PEG-b-PPG-b-PEG diacrylate polymer with a crosslink agent, pentaerythritol tetrakis(3- mercaptopropionate) (PETMP), in the presence of βCD end-capped chains, βCD-capped-PMES. The latter was prepared a priori by reversible addition-fragmentation chain transfer (RAFT) polymerization. Due to the controlled character of RAFT polymerization and the quantitative yield of thiol-ene click reaction, the as-synthesized PEG-b-PPG-b-PEG-thread-βCD- capped-PMES hydrogels have a well-defined PEG-b-PPG-b-PEG network and tunable PMES chain length. The length of PMES chains can be regulated by varying the molar ratio of 2-(methacryloyloxy)ethyl succinate (MES) monomer to RAFT agent. The molecular structures and thermal properties of the PEG-b-PPG-b-PEG-thread- βCD-capped-PMES hydrogels were studied by 1H NMR, XPS, TGA and DSC measurements. The polymer hydrogels with threaded sliding rings exhibit both pH- and temperature-dependent equilibrium swelling ratios in aqueous media and have potential applications as biomaterials and biomedical materials. © 2012 The Royal Society of Chemistry.
Source Title: Soft Matter
URI: http://scholarbank.nus.edu.sg/handle/10635/89924
ISSN: 1744683X
DOI: 10.1039/c2sm25368b
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