Please use this identifier to cite or link to this item:
|Title:||Preparation of stimuli-responsive hydrogel networks with threaded β-cyclodextrin end-capped chains via combination of controlled radical polymerization and click chemistry|
|Citation:||Cai, T., Yang, W.J., Zhang, Z., Zhu, X., Neoh, K.-G., Kang, E.-T. (2012-05-28). Preparation of stimuli-responsive hydrogel networks with threaded β-cyclodextrin end-capped chains via combination of controlled radical polymerization and click chemistry. Soft Matter 8 (20) : 5612-5620. ScholarBank@NUS Repository. https://doi.org/10.1039/c2sm25368b|
|Abstract:||Hydrogel networks of poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEG-b-PPG-b-PEG primary network), with threaded sliding β-cyclodextrin-capped poly(2-(methacryloyloxy)ethyl succinate) (βCD-capped-PMES) chains, are described. The hydrogels were prepared by UV-initiated thiol-ene click reaction of the PEG-b-PPG-b-PEG diacrylate polymer with a crosslink agent, pentaerythritol tetrakis(3- mercaptopropionate) (PETMP), in the presence of βCD end-capped chains, βCD-capped-PMES. The latter was prepared a priori by reversible addition-fragmentation chain transfer (RAFT) polymerization. Due to the controlled character of RAFT polymerization and the quantitative yield of thiol-ene click reaction, the as-synthesized PEG-b-PPG-b-PEG-thread-βCD- capped-PMES hydrogels have a well-defined PEG-b-PPG-b-PEG network and tunable PMES chain length. The length of PMES chains can be regulated by varying the molar ratio of 2-(methacryloyloxy)ethyl succinate (MES) monomer to RAFT agent. The molecular structures and thermal properties of the PEG-b-PPG-b-PEG-thread- βCD-capped-PMES hydrogels were studied by 1H NMR, XPS, TGA and DSC measurements. The polymer hydrogels with threaded sliding rings exhibit both pH- and temperature-dependent equilibrium swelling ratios in aqueous media and have potential applications as biomaterials and biomedical materials. © 2012 The Royal Society of Chemistry.|
|Source Title:||Soft Matter|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Oct 10, 2018
WEB OF SCIENCETM
checked on Oct 10, 2018
checked on Sep 21, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.