Please use this identifier to cite or link to this item: https://doi.org/10.1039/c2jm33419d
Title: Preparation of stimuli responsive polycaprolactone membranes of controllable porous morphology via combined atom transfer radical polymerization, ring-opening polymerization and thiol-yne click chemistry
Authors: Cai, T.
Li, M.
Neoh, K.-G. 
Kang, E.-T. 
Issue Date: 28-Aug-2012
Citation: Cai, T., Li, M., Neoh, K.-G., Kang, E.-T. (2012-08-28). Preparation of stimuli responsive polycaprolactone membranes of controllable porous morphology via combined atom transfer radical polymerization, ring-opening polymerization and thiol-yne click chemistry. Journal of Materials Chemistry 22 (32) : 16248-16258. ScholarBank@NUS Repository. https://doi.org/10.1039/c2jm33419d
Abstract: Linear di-block copolymers of poly(N-isopropylacrylamide) (PNIPAM) with a center disulfide linkage were prepared by atom transfer radical polymerization (ATRP) of N-isopropylacrylamide (NIPAM) using a bifunctional disulfide-based initiator. The center disulfide bond was cleaved by reduction with excess dl-1,4-dithiothreitol (DTT) to form thiols. The resulting thiol-terminated PNIPAM chains were conjugated to alkyne-terminated poly(ε-caprolactone) (PCL) via UV-initiated thiol-yne click reaction to produce the PCL-click-PNIPAM AB 2-type copolymers. The PCL-click-PNIPAM copolymers were cast by phase inversion in an aqueous medium into microporous membranes of well-defined and uniform pores. The PNIPAM content in the PCL-click-PNIPAM copolymers could be used to control the pore size and porosity of the resulting membranes. The PCL-click-PNIPAM-b-PNaSS membrane was prepared via surface-initiated ATRP of sodium 4-styrenesulfonate (NaSS) from the PCL-click-PNIPAM membrane and pore surfaces. The temperature and electrolyte responsive characteristics of the PCL-click-PNIPAM and PCL-click-PNIPAM-b-PNaSS membranes were illustrated in the swelling behavior and controlled glucose transport through the membranes. These stimuli responsive membranes with controllable morphology and low cytotoxicity have potential applications in biomedical engineering, drug delivery and tissue engineering. © The Royal Society of Chemistry 2012.
Source Title: Journal of Materials Chemistry
URI: http://scholarbank.nus.edu.sg/handle/10635/89923
ISSN: 09599428
DOI: 10.1039/c2jm33419d
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

31
checked on May 22, 2018

WEB OF SCIENCETM
Citations

31
checked on May 7, 2018

Page view(s)

41
checked on Feb 25, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.