Please use this identifier to cite or link to this item: https://doi.org/10.1002/marc.200600873
Title: Polypyrrole nanospheres with magnetic and cell-targeting capabilities
Authors: Wuang, S.C. 
Neoh, K.G. 
Kang, E.-T. 
Pack, D.W.
Leckband, D.E.
Keywords: Cancer cell-targeting
Emulsion polymerization
Hyaluronic acid
Polypyrrole/Fe3O4 nanospheres
Surfactants
Issue Date: 2-Apr-2007
Source: Wuang, S.C., Neoh, K.G., Kang, E.-T., Pack, D.W., Leckband, D.E. (2007-04-02). Polypyrrole nanospheres with magnetic and cell-targeting capabilities. Macromolecular Rapid Communications 28 (7) : 816-821. ScholarBank@NUS Repository. https://doi.org/10.1002/marc.200600873
Abstract: The preparation of polypyrrole/Fe3O4 nanospheres by a facile mini-emulsion polymerization method is investigated using poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), and hyaluronic acid as surfactants. Hyaluronic acid is deemed the most suitable surfactant since it results in well-dispersed nanospheres of 80-100 nm, and offers the advantages of biocompatibility, cell adhesive property, and the availability of functional groups for attachment of other molecules. These polypyrrole/Fe3O 4 nanospheres are magnetic and can be further functionalized with a cancer antibody, herceptin. Our results show that this combination of hyaluronic acid and herceptin results in high specific uptake of the nanospheres by cancer cells. © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.
Source Title: Macromolecular Rapid Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/89857
ISSN: 10221336
DOI: 10.1002/marc.200600873
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