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Title: Polymorphism and phase transformations of a cocrystal of nicotinamide and pimelic acid
Authors: Aitipamula, S.
Wong, A.B.H.
Chow, P.S.
Tan, R.B.H. 
Issue Date: 7-Dec-2012
Citation: Aitipamula, S., Wong, A.B.H., Chow, P.S., Tan, R.B.H. (2012-12-07). Polymorphism and phase transformations of a cocrystal of nicotinamide and pimelic acid. CrystEngComm 14 (23) : 8193-8198. ScholarBank@NUS Repository.
Abstract: With the overwhelming interest in pharmaceutical cocrystals, studies concerning polymorphism in multi-component crystals are becoming increasingly valuable. We present herein our polymorphism studies of a 1:1 cocrystal involving nicotinamide and pimelic acid. The polymorphs were unequivocally characterized by single-crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and hot-stage microscopy. Crystal structure analysis revealed different conformations of nicotinamide and pimelic acid. Thermal analysis and solid-state grinding experiments suggested an enantiotropic relationship between the polymorphs. Slurry experiments on powder samples of polymorphs revealed that the thermodynamic transition temperature lies between 85 and 90 °C, with Form 1 being the stable form at room temperature. © 2012 The Royal Society of Chemistry.
Source Title: CrystEngComm
ISSN: 14668033
Appears in Collections:Staff Publications

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