Please use this identifier to cite or link to this item:
|Title:||Phase sensitivity analysis of circadian rhythm entrainment|
|Authors:||Gunawan, R. |
Doyle III, F.J.
|Source:||Gunawan, R., Doyle III, F.J. (2007-04). Phase sensitivity analysis of circadian rhythm entrainment. Journal of Biological Rhythms 22 (2) : 180-194. ScholarBank@NUS Repository. https://doi.org/10.1177/0748730407299194|
|Abstract:||As a biological clock, circadian rhythms evolve to accomplish a stable (robust) entrainment to environmental cycles, of which light is the most obvious. The mechanism of photic entrainment is not known, but two models of entrainment have been proposed based on whether light has a continuous (parametric) or discrete (nonparametric) effect on the circadian pacemaker. A novel sensitivity analysis is developed to study the circadian entrainment in silico based on a limit cycle approach and applied to a model of Drosophila circadian rhythm. The comparative analyses of complete and skeleton photoperiods suggest a trade-off between the contribution of period modulation (parametric effect) and phase shift (nonparametric effect) in Drosophila circadian entrainment. The results also give suggestions for an experimental study to (in)validate the two models of entrainment. © 2007 Sage Publications.|
|Source Title:||Journal of Biological Rhythms|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 27, 2018
WEB OF SCIENCETM
checked on Feb 19, 2018
checked on Mar 12, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.